Effect of melatonin on the buccal mucosa of rats treated with fluorouracil and leucovorin calcium. Preliminary study on a model of experimental mucositis
Oral mucositis (OM) is an acute complication in patientsundergoing chemotherapy. It affects the soft tissues ofthe oral mucosa, causing delays in cancer treatment andnegatively impacting the patient’s quality of life. Clinicaland experimental research has sought to elucidate itsetiopathogenesis as w...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE)
2024
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| Materias: | |
| Acceso en línea: | https://revistas.unne.edu.ar/index.php/rfo/article/view/8053 |
| Aporte de: |
| Sumario: | Oral mucositis (OM) is an acute complication in patientsundergoing chemotherapy. It affects the soft tissues ofthe oral mucosa, causing delays in cancer treatment andnegatively impacting the patient’s quality of life. Clinicaland experimental research has sought to elucidate itsetiopathogenesis as well as to develop various pharmacologicalprotocols to minimize its deleterious effects onthe oral cavity. Several reports have described the multipurposeaction of melatonin as an antioxidant agent.This study evaluated superoxide dismutase levels andoxidative stress by quantifying lipid and aqueous peroxidesin an animal model of induced OM treated with theantineoplastic drug fluorouracil and its biomodulator,calcium leucovorin, as well as with melatonin administeredlocally and systemically.Five experimental groups (n=50) were established: G1:Control; G2: fluorouracil/calcium leucovorin; G3: fluorouracil/calcium leucovorin and induced OM; G4: fluorouracil/calcium leucovorin, induced OM, and topicalmelatonin; G5: fluorouracil/calcium leucovorin, inducedOM, and systemic melatonin. Superoxide dismutaseactivity in G3 was lower compared to G4 and G5. Lipidand aqueous peroxide concentrations were higherin G3 than in all treatment groups. Oxidative damagecaused by the deleterious action of the cytostatic agentwas identified in these tissues, alongside the protectivecapacity of melatonin. The exogenous administration ofmelatonin at the tested dose reversed the redox state ofthe buccal mucosa. |
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