Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits

Buffalo heifers supplemented with a mixture of sunflower oil + fish can produce milk with low level saturated fatty acids (SFA, which are considered hypercholesterolemic and pro-atherogenic), and increase the synthesis of trans-11 18: 1 and cis-9, trans-11 18: 2 fatty acids (with anti-atherogenic pr...

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Autores principales: Lertora, W J., Villordo, G I., Mussart, N B., Catuogno, M S., S.Negrette, M
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2019
Materias:
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/3895
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id I48-R154-article-3895
record_format ojs
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic Búfalas
ácidos grasos trans
colesterol
ateroesclerosis
Buffalos
trans fatty acids
cholesterol
atherosclerosis
spellingShingle Búfalas
ácidos grasos trans
colesterol
ateroesclerosis
Buffalos
trans fatty acids
cholesterol
atherosclerosis
Lertora, W J.
Villordo, G I.
Mussart, N B.
Catuogno, M S.
S.Negrette, M
Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
topic_facet Búfalas
ácidos grasos trans
colesterol
ateroesclerosis
Buffalos
trans fatty acids
cholesterol
atherosclerosis
author Lertora, W J.
Villordo, G I.
Mussart, N B.
Catuogno, M S.
S.Negrette, M
author_facet Lertora, W J.
Villordo, G I.
Mussart, N B.
Catuogno, M S.
S.Negrette, M
author_sort Lertora, W J.
title Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
title_short Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
title_full Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
title_fullStr Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
title_full_unstemmed Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
title_sort bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits
description Buffalo heifers supplemented with a mixture of sunflower oil + fish can produce milk with low level saturated fatty acids (SFA, which are considered hypercholesterolemic and pro-atherogenic), and increase the synthesis of trans-11 18: 1 and cis-9, trans-11 18: 2 fatty acids (with anti-atherogenic properties). This work compared the effects of the administration to rabbits of two bubaline milk, with low and high trans/saturated fatty acids (tFA/SFA) ratio, on the development of atherosclerosis induced by cholesterol. Twenty New Zealand rabbits, males, were randomly separated into a control group (n=10) that received milk with low tFA/SFA ratio (5.3% tFA and 67.12% SFA) obtained from grazing buffalos; and a high trans group (n = 10) that received milk with high tFA/SFA ratio (25.84% tFA and 45.89% SFA) obtained from buffalos with lipid supplementation in their diet. The experience lasted 75 days and, from day 15, all rabbits were challenged with 0.93 g of cholesterol/day orally, to induce atherosclerotic lesions. The rabbits voluntarily consumed 9293.13 ml and 9930 ml of milk with low and high tFA/SFA ratio, respectively (p 0.404). Rabbits that consumed milk with a high tFA/SFA ratio increased (p 0.049) serum levels of total cholesterol (6.08 g/l), compared to the control group (5.58 g/l). No differences were detected between groups in LDL cholesterol (p 0.073), HDL cholesterol (p 0.078) and triglycerides (p 0.174). Atherosclerotic lesions were more extensive in rabbits that consumed milk with a high tFA/SFA ratio, although without statistical significance (p> 0.05) compared to rabbits that consumed milk with low tFA/SFA ratio. In conclusion, bubaline milk obtained from animals with lipid supplementation contributed to increase cholesterolemia and tended to worsen atherosclerosis in rabbits. These effects may be related to the high content of tFA of this milk. 
publisher Universidad Nacional del Nordeste
publishDate 2019
url https://revistas.unne.edu.ar/index.php/vet/article/view/3895
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spelling I48-R154-article-38952025-02-12T21:58:56Z Bubaline milk with a high content of trans fatty acids increased cholesterolemia and tended to aggravate atherosclerosis in rabbits Una leche bubalina rica en ácidos grasos trans incrementó la colesterolemia y tendió a agravar la ateroesclerosis en conejos Lertora, W J. Villordo, G I. Mussart, N B. Catuogno, M S. S.Negrette, M Búfalas ácidos grasos trans colesterol ateroesclerosis Buffalos trans fatty acids cholesterol atherosclerosis Buffalo heifers supplemented with a mixture of sunflower oil + fish can produce milk with low level saturated fatty acids (SFA, which are considered hypercholesterolemic and pro-atherogenic), and increase the synthesis of trans-11 18: 1 and cis-9, trans-11 18: 2 fatty acids (with anti-atherogenic properties). This work compared the effects of the administration to rabbits of two bubaline milk, with low and high trans/saturated fatty acids (tFA/SFA) ratio, on the development of atherosclerosis induced by cholesterol. Twenty New Zealand rabbits, males, were randomly separated into a control group (n=10) that received milk with low tFA/SFA ratio (5.3% tFA and 67.12% SFA) obtained from grazing buffalos; and a high trans group (n = 10) that received milk with high tFA/SFA ratio (25.84% tFA and 45.89% SFA) obtained from buffalos with lipid supplementation in their diet. The experience lasted 75 days and, from day 15, all rabbits were challenged with 0.93 g of cholesterol/day orally, to induce atherosclerotic lesions. The rabbits voluntarily consumed 9293.13 ml and 9930 ml of milk with low and high tFA/SFA ratio, respectively (p 0.404). Rabbits that consumed milk with a high tFA/SFA ratio increased (p 0.049) serum levels of total cholesterol (6.08 g/l), compared to the control group (5.58 g/l). No differences were detected between groups in LDL cholesterol (p 0.073), HDL cholesterol (p 0.078) and triglycerides (p 0.174). Atherosclerotic lesions were more extensive in rabbits that consumed milk with a high tFA/SFA ratio, although without statistical significance (p> 0.05) compared to rabbits that consumed milk with low tFA/SFA ratio. In conclusion, bubaline milk obtained from animals with lipid supplementation contributed to increase cholesterolemia and tended to worsen atherosclerosis in rabbits. These effects may be related to the high content of tFA of this milk.  Búfalas suplementadas con una mezcla de aceites de girasol + pescado pueden reducir en la leche los niveles de ácidos grasos saturados (AGS), considerados hipercolesterolémicos y pro-aterogénicos, e incrementar los ácidos grasos trans-11 18:1 y cis-9,trans-11 18:2, con propiedades anti-aterogénicas. Este trabajo comparó los efectos del consumo de dos leches bubalinas, con baja y alta relación de ácidos grasos trans (AGt)/AGS, sobre el lipidograma y el desarrollo de ateroesclerosis inducidos por colesterol en conejos. Veinte conejos neozelandeses, machos, fueron aleatoriamente separados en un grupo control (n=10) que recibió leche con baja relación AGt/AGS (5,3% de AGt y 67,12% de AGS) obtenida de búfalas en sistema pastoril; y un grupo alto trans (n=10) que recibió leche con alta relación AGt/AGS (25,84% de AGt y 45,89% de AGS) obtenida de búfalas con suplementación lipídica en su dieta. La experiencia duró 75 días y, a partir del día 15, todos los conejos fueron desafiados con 0,93 g de colesterol/día, vía oral, a fin de inducir lesiones ateroescleróticas. Los conejos consumieron de manera voluntaria 9293,13 ml y 9930 ml de leche con baja y alta relación AGt/AGS, respectivamente (p 0,404). Los conejos que consumieron leche con alta relación AGt/AGS registraron un leve incremento significativo (p 0,049) del colesterol total (6,08 g/l), cuando se comparó con el grupo control (5,58 g/l). No se detectaron diferencias entre grupos en el colesterol LDL (p 0,073), colesterol HDL (p 0,078) y triglicéridos (p 0,174). Las lesiones ateroescleróticas fueron más extensas en los conejos que consumieron leche con alta relación AGt/AGS, aunque sin significación estadística (p>0,05) cuando se comparó el control. En conclusión, la leche bubalina obtenida con la suplementación lipídica referida en este estudio, incrementó la colesterolemia y tendió a agravar la ateroesclerosis en conejos. Dichos efectos, posiblemente estén relacionados con el alto contenido de AGt de esta leche.  Universidad Nacional del Nordeste 2019-08-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/3895 10.30972/vet.3013895 Revista Veterinaria; Vol. 30 Núm. 1 (2019); 32-38 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/3895/3516 Derechos de autor 2019 W J. Lertora, G I. Villordo, N B. Mussart, M S. Catuogno, M S.Negrette https://creativecommons.org/licenses/by-nc/4.0