Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle
Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/ PD) integration of i...
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| Formato: | Artículo |
| Lenguaje: | Español |
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2008
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| Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/4190/1/A_Baroni_D%C3%ADaz_Picco.pdf |
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I38-R144-41902025-05-07T18:22:50Z http://pa.bibdigital.ucc.edu.ar/4190/ Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle Baroni, Eduardo E. Díaz, Diego C. Picco, Eduardo J. Waxman, Samanta Rodriguez Fenández, Casilda San Andrés-Larrea, Manuel Ignacio Boggio, Juan Carlos SF Cultura de los animales Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/ PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥7 weeks-old cattle to reach a satisfactory dosage regimen (MIC≥32 μg/mL). 2008-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4190/1/A_Baroni_D%C3%ADaz_Picco.pdf Baroni, Eduardo E., Díaz, Diego C., Picco, Eduardo J., Waxman, Samanta, Rodriguez Fenández, Casilda, San Andrés-Larrea, Manuel Ignacio ORCID: https://orcid.org/0000-0003-1829-6113 <https://orcid.org/0000-0003-1829-6113> and Boggio, Juan Carlos ORCID: https://orcid.org/0000-0001-9748-001X <https://orcid.org/0000-0001-9748-001X> (2008) Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle. Veterinary Research Communications, 32 (7). pp. 509-519. ISSN 0165-7380 info:eu-repo/semantics/altIdentifier/doi/10.1007/s11259-008-9053-y |
| institution |
Universidad Católica de Córdoba |
| institution_str |
I-38 |
| repository_str |
R-144 |
| collection |
Producción Académica Universidad Católica de Córdoba (UCCor) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
SF Cultura de los animales |
| spellingShingle |
SF Cultura de los animales Baroni, Eduardo E. Díaz, Diego C. Picco, Eduardo J. Waxman, Samanta Rodriguez Fenández, Casilda San Andrés-Larrea, Manuel Ignacio Boggio, Juan Carlos Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| topic_facet |
SF Cultura de los animales |
| description |
Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/ PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥7 weeks-old cattle to reach a satisfactory dosage regimen (MIC≥32 μg/mL). |
| format |
Artículo |
| author |
Baroni, Eduardo E. Díaz, Diego C. Picco, Eduardo J. Waxman, Samanta Rodriguez Fenández, Casilda San Andrés-Larrea, Manuel Ignacio Boggio, Juan Carlos |
| author_facet |
Baroni, Eduardo E. Díaz, Diego C. Picco, Eduardo J. Waxman, Samanta Rodriguez Fenández, Casilda San Andrés-Larrea, Manuel Ignacio Boggio, Juan Carlos |
| author_sort |
Baroni, Eduardo E. |
| title |
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| title_short |
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| title_full |
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| title_fullStr |
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| title_full_unstemmed |
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| title_sort |
effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
| publishDate |
2008 |
| url |
http://pa.bibdigital.ucc.edu.ar/4190/1/A_Baroni_D%C3%ADaz_Picco.pdf |
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