Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis

Background: Allergic Conjunctivitis (AC) has a high incidence in the general population and sometimes it is difficult to make a correct diagnosis, distinguish among the different subtypes of AC, and therefore, to indicate the suitable therapy. Objective: To determine the best way to carry out an app...

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Autores principales: Martín, Andrea P., Gómez Demel, Eduardo, Gagliardi, Julio, Berra, Alejandro, Mariani, A.L., Baena Cagnani, Carlos E., Daraio, M.C., Urrets Zavalía, Julio, Urrets Zavalía, Enrique Alberto, Gallino, N., Serra, Horacio M.
Formato: Artículo
Lenguaje:Español
Publicado: 2003
Materias:
RE Oftalmología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3951/1/A_Mart%C3%ADn_G%C3%B3mezDemel_Gagliardi_Berra_Mariani_BaenaCagnani_%20Daraio_UrretsZaval%C3%ADa_UrretsZaval%C3%ADa_Gallino_Serra.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
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spelling I38-R144-39512025-04-11T18:45:34Z http://pa.bibdigital.ucc.edu.ar/3951/ Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis Martín, Andrea P. Gómez Demel, Eduardo Gagliardi, Julio Berra, Alejandro Mariani, A.L. Baena Cagnani, Carlos E. Daraio, M.C. Urrets Zavalía, Julio Urrets Zavalía, Enrique Alberto Gallino, N. Serra, Horacio M. RE Oftalmología Background: Allergic Conjunctivitis (AC) has a high incidence in the general population and sometimes it is difficult to make a correct diagnosis, distinguish among the different subtypes of AC, and therefore, to indicate the suitable therapy. Objective: To determine the best way to carry out an appropriate diagnosis of AC. Methods: Thirty-one patients with clinical manifestations of AC and eleven controls were studied by measuring allergic and immunologic parameters. Only those patients confirmed as having AC were treated with ketotifen fumarate and further evaluated. Results: According to allergic and immunological parameters patients were divided rate two groups. Group I patients had positive prick test toward at least one allergen, 60% exhibited high levels of tear-IgE, and only 36% conjunctival eosinophils. By contrast, patients from Group II had negative prick tests and laboratory findings similar to the control group. In Group I there was a good correlation between levels of tear-IgE and eosinophils (r = 0.55; p = 0.009); key symptoms and signs and prick test (r = 0.52; p = 0.015), and prick test and eosinophils (r = 0.50 p = 0.022). The cardinal signs and symptoms scores dropped significantly in Group I as a consequence of the treatment (p < 0.0001). Conclusion: In order to have a reliable AC diagnosis, allergen-skin prick test. IgE in tears, and conjunctival eosinophils must be studied. Serum IgE is less important. 2003-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3951/1/A_Mart%C3%ADn_G%C3%B3mezDemel_Gagliardi_Berra_Mariani_BaenaCagnani_%20Daraio_UrretsZaval%C3%ADa_UrretsZaval%C3%ADa_Gallino_Serra.pdf Martín, Andrea P., Gómez Demel, Eduardo, Gagliardi, Julio, Berra, Alejandro, Mariani, A.L., Baena Cagnani, Carlos E., Daraio, M.C., Urrets Zavalía, Julio ORCID: https://orcid.org/0000-0003-2267-2783 <https://orcid.org/0000-0003-2267-2783>, Urrets Zavalía, Enrique Alberto, Gallino, N. and Serra, Horacio M. ORCID: https://orcid.org/0000-0003-4979-8642 <https://orcid.org/0000-0003-4979-8642> (2003) Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis. Journal of Investigational Allergology and Clinical Immunology, 13 (4). pp. 232-237. ISSN 1018-9068
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic RE Oftalmología
spellingShingle RE Oftalmología
Martín, Andrea P.
Gómez Demel, Eduardo
Gagliardi, Julio
Berra, Alejandro
Mariani, A.L.
Baena Cagnani, Carlos E.
Daraio, M.C.
Urrets Zavalía, Julio
Urrets Zavalía, Enrique Alberto
Gallino, N.
Serra, Horacio M.
Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
topic_facet RE Oftalmología
description Background: Allergic Conjunctivitis (AC) has a high incidence in the general population and sometimes it is difficult to make a correct diagnosis, distinguish among the different subtypes of AC, and therefore, to indicate the suitable therapy. Objective: To determine the best way to carry out an appropriate diagnosis of AC. Methods: Thirty-one patients with clinical manifestations of AC and eleven controls were studied by measuring allergic and immunologic parameters. Only those patients confirmed as having AC were treated with ketotifen fumarate and further evaluated. Results: According to allergic and immunological parameters patients were divided rate two groups. Group I patients had positive prick test toward at least one allergen, 60% exhibited high levels of tear-IgE, and only 36% conjunctival eosinophils. By contrast, patients from Group II had negative prick tests and laboratory findings similar to the control group. In Group I there was a good correlation between levels of tear-IgE and eosinophils (r = 0.55; p = 0.009); key symptoms and signs and prick test (r = 0.52; p = 0.015), and prick test and eosinophils (r = 0.50 p = 0.022). The cardinal signs and symptoms scores dropped significantly in Group I as a consequence of the treatment (p < 0.0001). Conclusion: In order to have a reliable AC diagnosis, allergen-skin prick test. IgE in tears, and conjunctival eosinophils must be studied. Serum IgE is less important.
format Artículo
author Martín, Andrea P.
Gómez Demel, Eduardo
Gagliardi, Julio
Berra, Alejandro
Mariani, A.L.
Baena Cagnani, Carlos E.
Daraio, M.C.
Urrets Zavalía, Julio
Urrets Zavalía, Enrique Alberto
Gallino, N.
Serra, Horacio M.
author_facet Martín, Andrea P.
Gómez Demel, Eduardo
Gagliardi, Julio
Berra, Alejandro
Mariani, A.L.
Baena Cagnani, Carlos E.
Daraio, M.C.
Urrets Zavalía, Julio
Urrets Zavalía, Enrique Alberto
Gallino, N.
Serra, Horacio M.
author_sort Martín, Andrea P.
title Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
title_short Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
title_full Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
title_fullStr Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
title_full_unstemmed Clinical Signs and Symptoms are not Enough for the Correct Diagnosis of Allergic Conjunctivitis
title_sort clinical signs and symptoms are not enough for the correct diagnosis of allergic conjunctivitis
publishDate 2003
url http://pa.bibdigital.ucc.edu.ar/3951/1/A_Mart%C3%ADn_G%C3%B3mezDemel_Gagliardi_Berra_Mariani_BaenaCagnani_%20Daraio_UrretsZaval%C3%ADa_UrretsZaval%C3%ADa_Gallino_Serra.pdf
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