Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis

Background: Multiple white plaques of the oral mucosa are usually associated with potentially malignant disorders such as oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia. Previous studies in the current literature describe a potential clinical overlap in these enti...

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Autores principales: Gilligan, Gerardo, Garola, Federico, Piemonte, Eduardo David, Leonardi, Nicolás, Panico, René Luis, Warnakulasuriya, Saman
Formato: Artículo
Lenguaje:Español
Publicado: Blackwell Publishing Ltd 2021
Materias:
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
RK Odontología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3477/1/A_Gilligan_Garola_Piemonte.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3477
record_format dspace
spelling I38-R144-34772023-05-18T16:02:39Z http://pa.bibdigital.ucc.edu.ar/3477/ Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis Gilligan, Gerardo Garola, Federico Piemonte, Eduardo David Leonardi, Nicolás Panico, René Luis Warnakulasuriya, Saman RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer) RK Odontología Background: Multiple white plaques of the oral mucosa are usually associated with potentially malignant disorders such as oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia. Previous studies in the current literature describe a potential clinical overlap in these entities. The aim of this study is to review clinicopathological and evolutive features of these Oral Potentially Malignant Disorders highlighting the dynamic changes of diagnoses. Discussion: It was previously hypothesized that a subset of patients with oral lichen planus or oral lichenoid diagnosis, could develop multiple white plaques during the natural history of the disease, fulfilling diagnostic criteria for proliferative verrucous leukoplakia. Consequently, these entities could, under certain conditions, obey a continuum of the same precancerous condition in the context of the field cancerization theory, increasing the risk of malignant transformation. Nevertheless, there is limited scientific evidence concerning this issue. Conclusion: Further studies are needed to understand the biological and evolutive features of the link between these oral potentially malignant disorders. Regardless of its diagnosis, these patients with multifocal white lesions must be carefully monitored to detect early malignant transformation. Blackwell Publishing Ltd 2021-02 application/pdf spa http://pa.bibdigital.ucc.edu.ar/3477/1/A_Gilligan_Garola_Piemonte.pdf Gilligan, Gerardo, Garola, Federico, Piemonte, Eduardo David, Leonardi, Nicolás, Panico, René Luis ORCID: https://orcid.org/0000-0002-5833-5546 <https://orcid.org/0000-0002-5833-5546> and Warnakulasuriya, Saman ORCID: https://orcid.org/0000-0003-2103-0746 <https://orcid.org/0000-0003-2103-0746> (2021) Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis. Journal of Oral Pathology and Medicine, 50 (2). ISSN 0904-2512 https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1111%2fjop.13133&locationID=1&categoryID=4&eid=2-s2.0-85098243118&issn=09042512&linkType=ViewAtPublisher&year=2021&origin=recordpage&dig=c13660f485ec0a11ae815fdaaf6789a1 info:eu-repo/semantics/altIdentifier/doi/10.1111/jop.13133 info:eu-repo/semantics/article info:ar-repo/semantics/artículo Fil: Gilligan, Gerardo. Universidad Nacional de Córdoba. Facultad de Odontología. Oral Medicine Department; Argentina Fil: Garola, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Oral Medicine Department; Argentina Fil: Piemonte, Eduardo. Universidad Nacional de Córdoba. Facultad de Odontología. Oral Medicine Department; Argentina Fil: Leonardi, Nicolás. Universidad Católica de Córdoba. Health Sciences Faculty. Dentistry School. Oral Medicine Department; Argentina Fil: Panico, René. Universidad Nacional de Córdoba. Facultad de Odontología. Oral Medicine Department; Argentina Fil: Warnakulasuriya, Saman. WHO Collaborating Centre for Oral Cancer. King's College London. Faculty of Dentistry, Oral & Craniofacial Sciences; Reino Unido info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
RK Odontología
spellingShingle RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
RK Odontología
Gilligan, Gerardo
Garola, Federico
Piemonte, Eduardo David
Leonardi, Nicolás
Panico, René Luis
Warnakulasuriya, Saman
Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
topic_facet RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
RK Odontología
description Background: Multiple white plaques of the oral mucosa are usually associated with potentially malignant disorders such as oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia. Previous studies in the current literature describe a potential clinical overlap in these entities. The aim of this study is to review clinicopathological and evolutive features of these Oral Potentially Malignant Disorders highlighting the dynamic changes of diagnoses. Discussion: It was previously hypothesized that a subset of patients with oral lichen planus or oral lichenoid diagnosis, could develop multiple white plaques during the natural history of the disease, fulfilling diagnostic criteria for proliferative verrucous leukoplakia. Consequently, these entities could, under certain conditions, obey a continuum of the same precancerous condition in the context of the field cancerization theory, increasing the risk of malignant transformation. Nevertheless, there is limited scientific evidence concerning this issue. Conclusion: Further studies are needed to understand the biological and evolutive features of the link between these oral potentially malignant disorders. Regardless of its diagnosis, these patients with multifocal white lesions must be carefully monitored to detect early malignant transformation.
format Artículo
Artículo
author Gilligan, Gerardo
Garola, Federico
Piemonte, Eduardo David
Leonardi, Nicolás
Panico, René Luis
Warnakulasuriya, Saman
author_facet Gilligan, Gerardo
Garola, Federico
Piemonte, Eduardo David
Leonardi, Nicolás
Panico, René Luis
Warnakulasuriya, Saman
author_sort Gilligan, Gerardo
title Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
title_short Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
title_full Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
title_fullStr Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
title_full_unstemmed Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis
title_sort lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? a revised hypothesis
publisher Blackwell Publishing Ltd
publishDate 2021
url http://pa.bibdigital.ucc.edu.ar/3477/1/A_Gilligan_Garola_Piemonte.pdf
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