Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth

Acyline contraception has been described in cats, but few data are available on the drug's long-term effect on growth. The relevant data cover until puberty with no radiographic description. We investigated the radiographic parameters throughout bone growth in order to more completely determine...

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Detalles Bibliográficos
Autores principales: Priotto, Marcelo, Faya, Marcela Inés, Romero, Mariela Grisolia, Marchetti, Cynthia, Rodríguez, Marcelo, Gobello, Cristina, Furlán, Paulina
Formato: Artículo
Lenguaje:Español
Publicado: NLM (Medline) 2022
Materias:
Q Ciencia (General)
QH301 Biología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3424/1/A_Priotto_Faya_Romero.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3424
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic Q Ciencia (General)
QH301 Biología
spellingShingle Q Ciencia (General)
QH301 Biología
Priotto, Marcelo
Faya, Marcela Inés
Romero, Mariela Grisolia
Marchetti, Cynthia
Rodríguez, Marcelo
Gobello, Cristina
Furlán, Paulina
Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
topic_facet Q Ciencia (General)
QH301 Biología
description Acyline contraception has been described in cats, but few data are available on the drug's long-term effect on growth. The relevant data cover until puberty with no radiographic description. We investigated the radiographic parameters throughout bone growth in order to more completely determine the drug's safety. Thirteen male and 12 female cats were studied, with the kittens being randomly assigned to one of the following groups within the first 24 hours of birth: ACY, subcutaneous acyline, 33 µg/100 g, which injection was repeated weekly until age 3 months; or CO, untreated control. Body measurements were recorded weekly and radiographic parameters obtained from monthly radiographs of the antebrachium. In the ACY and CO male and female kittens, the body weight, withers height, and body length plus the age at the end of body growth and radial growth remained similar throughout the study (P> .05). Both female groups finished radial growth before the males (P< .05). The ACY females evidenced a longer radial length between the eighth and 28th weeks (P< .05). All groups closed their proximal and distal physes within the normal ranges described for the species. The bone-cortex width was lower in the ACY vs. the CO animals at weeks 52 and 60 in the males and at weeks 24, 48, 52, and 56 in the females (P< .05) The transient greater radial length and lower bone-cortex thickness observed in the treated cats were compensated for at the end of growth with no adverse clinical effects being observed. In conclusion, acyline as a contraceptive did not evidence a permanent or severe effect on domestic-cat growth.
format Artículo
Artículo
author Priotto, Marcelo
Faya, Marcela Inés
Romero, Mariela Grisolia
Marchetti, Cynthia
Rodríguez, Marcelo
Gobello, Cristina
Furlán, Paulina
author_facet Priotto, Marcelo
Faya, Marcela Inés
Romero, Mariela Grisolia
Marchetti, Cynthia
Rodríguez, Marcelo
Gobello, Cristina
Furlán, Paulina
author_sort Priotto, Marcelo
title Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
title_short Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
title_full Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
title_fullStr Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
title_full_unstemmed Evaluation of Long-Term Effects of the Gonadotrophin-Releasing-Hormone Antagonist Acyline on Domestic-Cat Growth
title_sort evaluation of long-term effects of the gonadotrophin-releasing-hormone antagonist acyline on domestic-cat growth
publisher NLM (Medline)
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3424/1/A_Priotto_Faya_Romero.pdf
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