Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype

Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort...

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Autores principales: Martín-Nares, Eduardo, Baenas, Diego Federico, Cuellar Gutiérrez, María Carolina, Hernández-Molina, Gabriela, Ortiz, Alberto Christian, Neira, Oscar, Gutiérrez, Miguel A., Calvo, Romina, Saad, Emanuel José, Elgueta Pinochet, Sergio, Gallo, Jesica, Herrera Moya, Alejandra, Mansilla Aravena, Bellanides Agustina, Crespo Espíndola, María Elena, Cairoli, Ernesto, Bertoli, Ana María, Córdoba, Mercedes, Wurmann Kiblisky, Pamela, Basualdo Arancibia, Washington Javier, Badilla Piñeiro, María Natalia, Gobbi, Carla Andrea, Berbotto, Guillermo Ariel, Pisoni, Cecilia N., Juárez, Vicente, Cosatti, Micaela Ana, Aste, Nora María, Airoldi, Carla, Llanos, Carolina, Vergara Melian, Cristian Fabián, Erlij Opazo, Daniel, Goecke, Annelise, Pastenes Montaño, Paula Andrea, Tate, Patricio, Pirola, Juan Pablo, Stange Núñez, Lilith, Burgos, Paula I., Mezzano Robinson, María Verónica, Michalland H, Susana, Silva Labra, Francisco, Labarca Solar, Cristián Humberto, Lencina, María Verónica, Izquierdo Loaiza, Jorge Hernán, Del Castillo Gil, David Julián, Caeiro, Francisco, Paira, Sergio
Formato: Artículo
Lenguaje:Español
Publicado: Lippincott Williams and Wilkins 2022
Materias:
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3334/1/Mart%C3%ADn-Nares_Baenas_Cuellar.pdf
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id I38-R144-3334
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Martín-Nares, Eduardo
Baenas, Diego Federico
Cuellar Gutiérrez, María Carolina
Hernández-Molina, Gabriela
Ortiz, Alberto Christian
Neira, Oscar
Gutiérrez, Miguel A.
Calvo, Romina
Saad, Emanuel José
Elgueta Pinochet, Sergio
Gallo, Jesica
Herrera Moya, Alejandra
Mansilla Aravena, Bellanides Agustina
Crespo Espíndola, María Elena
Cairoli, Ernesto
Bertoli, Ana María
Córdoba, Mercedes
Wurmann Kiblisky, Pamela
Basualdo Arancibia, Washington Javier
Badilla Piñeiro, María Natalia
Gobbi, Carla Andrea
Berbotto, Guillermo Ariel
Pisoni, Cecilia N.
Juárez, Vicente
Cosatti, Micaela Ana
Aste, Nora María
Airoldi, Carla
Llanos, Carolina
Vergara Melian, Cristian Fabián
Erlij Opazo, Daniel
Goecke, Annelise
Pastenes Montaño, Paula Andrea
Tate, Patricio
Pirola, Juan Pablo
Stange Núñez, Lilith
Burgos, Paula I.
Mezzano Robinson, María Verónica
Michalland H, Susana
Silva Labra, Francisco
Labarca Solar, Cristián Humberto
Lencina, María Verónica
Izquierdo Loaiza, Jorge Hernán
Del Castillo Gil, David Julián
Caeiro, Francisco
Paira, Sergio
Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
topic_facet R Medicina (General)
description Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results The mean age was 50.8 ± 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance. Conclusions Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype.
format Artículo
author Martín-Nares, Eduardo
Baenas, Diego Federico
Cuellar Gutiérrez, María Carolina
Hernández-Molina, Gabriela
Ortiz, Alberto Christian
Neira, Oscar
Gutiérrez, Miguel A.
Calvo, Romina
Saad, Emanuel José
Elgueta Pinochet, Sergio
Gallo, Jesica
Herrera Moya, Alejandra
Mansilla Aravena, Bellanides Agustina
Crespo Espíndola, María Elena
Cairoli, Ernesto
Bertoli, Ana María
Córdoba, Mercedes
Wurmann Kiblisky, Pamela
Basualdo Arancibia, Washington Javier
Badilla Piñeiro, María Natalia
Gobbi, Carla Andrea
Berbotto, Guillermo Ariel
Pisoni, Cecilia N.
Juárez, Vicente
Cosatti, Micaela Ana
Aste, Nora María
Airoldi, Carla
Llanos, Carolina
Vergara Melian, Cristian Fabián
Erlij Opazo, Daniel
Goecke, Annelise
Pastenes Montaño, Paula Andrea
Tate, Patricio
Pirola, Juan Pablo
Stange Núñez, Lilith
Burgos, Paula I.
Mezzano Robinson, María Verónica
Michalland H, Susana
Silva Labra, Francisco
Labarca Solar, Cristián Humberto
Lencina, María Verónica
Izquierdo Loaiza, Jorge Hernán
Del Castillo Gil, David Julián
Caeiro, Francisco
Paira, Sergio
author_facet Martín-Nares, Eduardo
Baenas, Diego Federico
Cuellar Gutiérrez, María Carolina
Hernández-Molina, Gabriela
Ortiz, Alberto Christian
Neira, Oscar
Gutiérrez, Miguel A.
Calvo, Romina
Saad, Emanuel José
Elgueta Pinochet, Sergio
Gallo, Jesica
Herrera Moya, Alejandra
Mansilla Aravena, Bellanides Agustina
Crespo Espíndola, María Elena
Cairoli, Ernesto
Bertoli, Ana María
Córdoba, Mercedes
Wurmann Kiblisky, Pamela
Basualdo Arancibia, Washington Javier
Badilla Piñeiro, María Natalia
Gobbi, Carla Andrea
Berbotto, Guillermo Ariel
Pisoni, Cecilia N.
Juárez, Vicente
Cosatti, Micaela Ana
Aste, Nora María
Airoldi, Carla
Llanos, Carolina
Vergara Melian, Cristian Fabián
Erlij Opazo, Daniel
Goecke, Annelise
Pastenes Montaño, Paula Andrea
Tate, Patricio
Pirola, Juan Pablo
Stange Núñez, Lilith
Burgos, Paula I.
Mezzano Robinson, María Verónica
Michalland H, Susana
Silva Labra, Francisco
Labarca Solar, Cristián Humberto
Lencina, María Verónica
Izquierdo Loaiza, Jorge Hernán
Del Castillo Gil, David Julián
Caeiro, Francisco
Paira, Sergio
author_sort Martín-Nares, Eduardo
title Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
title_short Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
title_full Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
title_fullStr Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
title_full_unstemmed Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
title_sort clinical and serological features in latin american igg4-related disease patients differ according to sex, ethnicity, and clinical phenotype
publisher Lippincott Williams and Wilkins
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3334/1/Mart%C3%ADn-Nares_Baenas_Cuellar.pdf
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spelling I38-R144-33342025-04-11T18:12:53Z http://pa.bibdigital.ucc.edu.ar/3334/ Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype Martín-Nares, Eduardo Baenas, Diego Federico Cuellar Gutiérrez, María Carolina Hernández-Molina, Gabriela Ortiz, Alberto Christian Neira, Oscar Gutiérrez, Miguel A. Calvo, Romina Saad, Emanuel José Elgueta Pinochet, Sergio Gallo, Jesica Herrera Moya, Alejandra Mansilla Aravena, Bellanides Agustina Crespo Espíndola, María Elena Cairoli, Ernesto Bertoli, Ana María Córdoba, Mercedes Wurmann Kiblisky, Pamela Basualdo Arancibia, Washington Javier Badilla Piñeiro, María Natalia Gobbi, Carla Andrea Berbotto, Guillermo Ariel Pisoni, Cecilia N. Juárez, Vicente Cosatti, Micaela Ana Aste, Nora María Airoldi, Carla Llanos, Carolina Vergara Melian, Cristian Fabián Erlij Opazo, Daniel Goecke, Annelise Pastenes Montaño, Paula Andrea Tate, Patricio Pirola, Juan Pablo Stange Núñez, Lilith Burgos, Paula I. Mezzano Robinson, María Verónica Michalland H, Susana Silva Labra, Francisco Labarca Solar, Cristián Humberto Lencina, María Verónica Izquierdo Loaiza, Jorge Hernán Del Castillo Gil, David Julián Caeiro, Francisco Paira, Sergio R Medicina (General) Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results The mean age was 50.8 ± 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance. Conclusions Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype. Lippincott Williams and Wilkins 2022 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3334/1/Mart%C3%ADn-Nares_Baenas_Cuellar.pdf Martín-Nares, Eduardo, Baenas, Diego Federico, Cuellar Gutiérrez, María Carolina, Hernández-Molina, Gabriela, Ortiz, Alberto Christian, Neira, Oscar, Gutiérrez, Miguel A., Calvo, Romina, Saad, Emanuel José, Elgueta Pinochet, Sergio, Gallo, Jesica, Herrera Moya, Alejandra, Mansilla Aravena, Bellanides Agustina, Crespo Espíndola, María Elena, Cairoli, Ernesto ORCID: https://orcid.org/0000-0003-3210-3824 <https://orcid.org/0000-0003-3210-3824>, Bertoli, Ana María ORCID: https://orcid.org/0000-0002-9335-075X <https://orcid.org/0000-0002-9335-075X>, Córdoba, Mercedes, Wurmann Kiblisky, Pamela, Basualdo Arancibia, Washington Javier, Badilla Piñeiro, María Natalia, Gobbi, Carla Andrea, Berbotto, Guillermo Ariel, Pisoni, Cecilia N., Juárez, Vicente, Cosatti, Micaela Ana, Aste, Nora María, Airoldi, Carla, Llanos, Carolina, Vergara Melian, Cristian Fabián, Erlij Opazo, Daniel, Goecke, Annelise, Pastenes Montaño, Paula Andrea, Tate, Patricio, Pirola, Juan Pablo, Stange Núñez, Lilith, Burgos, Paula I., Mezzano Robinson, María Verónica, Michalland H, Susana, Silva Labra, Francisco, Labarca Solar, Cristián Humberto, Lencina, María Verónica, Izquierdo Loaiza, Jorge Hernán, Del Castillo Gil, David Julián, Caeiro, Francisco and Paira, Sergio (2022) Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype. Journal of Clinical Rheumatology, 28 (6). pp. 285-292. ISSN 1076-1608 https://journals.lww.com/jclinrheum/Abstract/2022/09000/Clinical_and_Serological_Features_in_Latin.1.aspx info:eu-repo/semantics/altIdentifier/doi/10.1097/RHU.0000000000001858