Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]

Introduction: Measurement of the exhaled nitric oxide fraction (FeNO) has been proposed as an indirect and non-invasive method to detect eosinophilic airway inflammation. Allergic rhinitis (AR) is frequently associated with high levels of FeNO. Allergic sensitization can contribute to the recruitmen...

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Autores principales: Saranz, Ricardo José dir., Lozano, Natalia Andrea, Lozano, Alejandro, Alegre, Graciela, Robredo, Paula, Visconti, Pilar, Cruz, Álvaro A.
Formato: Artículo
Lenguaje:Español
Publicado: Sociedad Espanola de Otorrinolaringologia y Cirugia de Cabeza y Cuello 2021
Materias:
R Medicina (General)
RF Otorrinolaringología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3309/1/A_Saranz_Lozano_Lozano.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3309
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RF Otorrinolaringología
spellingShingle R Medicina (General)
RF Otorrinolaringología
Saranz, Ricardo José dir.
Lozano, Natalia Andrea
Lozano, Alejandro
Alegre, Graciela
Robredo, Paula
Visconti, Pilar
Cruz, Álvaro A.
Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
topic_facet R Medicina (General)
RF Otorrinolaringología
description Introduction: Measurement of the exhaled nitric oxide fraction (FeNO) has been proposed as an indirect and non-invasive method to detect eosinophilic airway inflammation. Allergic rhinitis (AR) is frequently associated with high levels of FeNO. Allergic sensitization can contribute to the recruitment of eosinophils in the airway and the consequent increase in FeNO. Objective: To correlate FeNO values with inflammatory and atopic sensitization biomarkers in patients with AR. Patients and methods: Observational, analytical, cross-sectional study. Children and adolescents with AR without asthma were included. FeNO, blood eosinophil count, total serum IgE were determined and skin tests with aeroallergens were performed by calculating the scores for PPC1 (number of positive allergens), STS2 (sum of millimeters of positive papules) and the atopy index (ratio between STS2/STS1). Spearman's correlation test was used between FeNO and variables of inflammation and atopy. Results: Twenty-eight patients between 6 and 17 years old were included. There was a significant positive correlation between FeNO and blood eosinophils (r = .38; p = .047) and between FeNO and the atopy index (r = .40; p = .03). No correlation was found between FeNO and total serum IgE (r = .24; p = .21), STS1 (r = .20; p = .32) and STS2 (r = .34; p = .08). Conclusion: In children and adolescents with AR, FeNO was correlated with the atopy index and the blood eosinophil count. These last biomarkers could be used as alternatives for FeNO as biomarkers of lower airway inflammation in patients with AR.
format Artículo
Artículo
author Saranz, Ricardo José dir.
Lozano, Natalia Andrea
Lozano, Alejandro
Alegre, Graciela
Robredo, Paula
Visconti, Pilar
Cruz, Álvaro A.
author_facet Saranz, Ricardo José dir.
Lozano, Natalia Andrea
Lozano, Alejandro
Alegre, Graciela
Robredo, Paula
Visconti, Pilar
Cruz, Álvaro A.
author_sort Saranz, Ricardo José dir.
title Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
title_short Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
title_full Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
title_fullStr Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
title_full_unstemmed Relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[Relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
title_sort relationship between exhaled nitric oxide and biomarkers of atopy in children and adolescents with allergic rhinitis[relación entre el óxido nítrico exhalado y los biomarcadores de atopia en niños y adolescentes con rinitis alérgica]
publisher Sociedad Espanola de Otorrinolaringologia y Cirugia de Cabeza y Cuello
publishDate 2021
url http://pa.bibdigital.ucc.edu.ar/3309/1/A_Saranz_Lozano_Lozano.pdf
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