A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity

An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteria, we developed a thermostable, orally administere...

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Autores principales: Bellier, Bertrand, Saura, Alicia, Luján, Lucas A., Molina, Cecilia R., Luján, Hugo Daniel, Klatzmann, David
Formato: Artículo
Lenguaje:Español
Publicado: Frontiers Media S.A. 2022
Materias:
Q Ciencia (General)
QR180 Inmunología
QR355 Virología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3253/1/A_Saura_Luj%C3%A1n_Luj%C3%A1n.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3253
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic Q Ciencia (General)
QR180 Inmunología
QR355 Virología
spellingShingle Q Ciencia (General)
QR180 Inmunología
QR355 Virología
Bellier, Bertrand
Saura, Alicia
Luján, Lucas A.
Molina, Cecilia R.
Luján, Hugo Daniel
Klatzmann, David
A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
topic_facet Q Ciencia (General)
QR180 Inmunología
QR355 Virología
description An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteria, we developed a thermostable, orally administered vaccine that can induce a robust mucosal neutralizing immune response. We used our platform based on retrovirus-derived enveloped virus-like particles (eVLPs) harnessed with variable surface proteins (VSPs) from the intestinal parasite Giardia lamblia, affording them resistance to degradation and the triggering of robust mucosal cellular and antibody immune responses after oral administration. We made eVLPs expressing various forms of the SARS-CoV-2 Spike protein (S), with or without membrane protein (M) expression. We found that prime-boost administration of VSP-decorated eVLPs expressing a pre-fusion stabilized form of S and M triggers robust mucosal responses against SARS-CoV-2 in mice and hamsters, which translate into complete protection from a viral challenge. Moreover, they dramatically boosted the IgA mucosal response of intramuscularly injected vaccines. We conclude that our thermostable orally administered eVLP vaccine could be a valuable addition to the current arsenal against SARS-CoV-2, in a stand-alone prime-boost vaccination strategy or as a boost for existing vaccines.
format Artículo
Artículo
author Bellier, Bertrand
Saura, Alicia
Luján, Lucas A.
Molina, Cecilia R.
Luján, Hugo Daniel
Klatzmann, David
author_facet Bellier, Bertrand
Saura, Alicia
Luján, Lucas A.
Molina, Cecilia R.
Luján, Hugo Daniel
Klatzmann, David
author_sort Bellier, Bertrand
title A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
title_short A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
title_full A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
title_fullStr A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
title_full_unstemmed A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity
title_sort thermostable oral sars-cov-2 vaccine induces mucosal and protective immunity
publisher Frontiers Media S.A.
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3253/1/A_Saura_Luj%C3%A1n_Luj%C3%A1n.pdf
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