The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors
DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co-repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C-ter and N-ter regions, including the nuclear localizatio...
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| Lenguaje: | Español |
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Wiley-Blackwell
2022
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| Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/3210/1/A_Quintero_Pagnoni_Jacquelin.pdf |
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I38-R144-32102023-05-24T16:06:17Z http://pa.bibdigital.ucc.edu.ar/3210/ The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors Quintero, Julieta Saad, Nizar Y. Pagnoni, Sabrina M. Jacquelin, Daniela K. Gatica, Laura V. Harper, Scott Q. Rosa, Alberto Luis dir. QD Química QM Anatomía humana DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co-repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C-ter and N-ter regions, including the nuclear localization signals and homeodomain motifs, contribute to the co-repressor activity of DUX4 on PR and GR. Immunoprecipitation studies, using total protein extracts of cells expressing tagged versions of DUX4 and GR, support that these proteins are physically associated. Our studies suggest that DUX4 could modulate gene expression by co-regulating the activity of hormone NRs. This is the first report highlighting a potential endocrine role for DUX4. Wiley-Blackwell 2022-06-03 application/pdf spa http://pa.bibdigital.ucc.edu.ar/3210/1/A_Quintero_Pagnoni_Jacquelin.pdf Quintero, Julieta, Saad, Nizar Y., Pagnoni, Sabrina M., Jacquelin, Daniela K., Gatica, Laura V., Harper, Scott Q. and Rosa, Alberto Luis dir. ORCID: https://orcid.org/0000-0001-8701-4525 <https://orcid.org/0000-0001-8701-4525> (2022) The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors. FEBS Letters. ISSN 0014-5793 https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14416 info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14416 info:eu-repo/semantics/article info:ar-repo/semantics/artículo Fil: Quintero, Julieta. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Genética y Biología Molecular. IRNASUS-CONICET; Argentina. Fil: Saad, Nizar Y. The Research Institute at Nationwide Children's Hospital. Center for Gene Therapy; Columbus, OH, United States. Fil: Saad, Nizar Y. The Ohio State University College of Medicine. Department of Pediatrics; Columbus, OH, United States. Fil: Jacquelin, Daniela K. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Genética y Biología Molecular. IRNASUS-CONICET; Argentina. Fil: Jacquelin, Daniela K. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. INFIQC-CONICET; Argentina. Fil: Gatica, Laura V. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Genética y Biología Molecular. IRNASUS-CONICET; Argentina. Fil: Gatica, Laura V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. CIBICI-CONICET; Argentina. Fil: Harper, Scott Q. The Research Institute at Nationwide Children's Hospital. Center for Gene Therapy; Columbus, OH, United States. Fil: Harper, Scott Q. The Ohio State University College of Medicine. Department of Pediatrics; Columbus, OH, United States. Fil: Rosa, Alberto L. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Genética y Biología Molecular. IRNASUS-CONICET; Argentina. Fil: Rosa, Alberto L. Fundación Allende-CONICET; Argentina. info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| institution |
Universidad Católica de Córdoba |
| institution_str |
I-38 |
| repository_str |
R-144 |
| collection |
Producción Académica Universidad Católica de Córdoba (UCCor) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
QD Química QM Anatomía humana |
| spellingShingle |
QD Química QM Anatomía humana Quintero, Julieta Saad, Nizar Y. Pagnoni, Sabrina M. Jacquelin, Daniela K. Gatica, Laura V. Harper, Scott Q. Rosa, Alberto Luis dir. The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| topic_facet |
QD Química QM Anatomía humana |
| description |
DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co-repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C-ter and N-ter regions, including the nuclear localization signals and homeodomain motifs, contribute to the co-repressor activity of DUX4 on PR and GR. Immunoprecipitation studies, using total protein extracts of cells expressing tagged versions of DUX4 and GR, support that these proteins are physically associated. Our studies suggest that DUX4 could modulate gene expression by co-regulating the activity of hormone NRs. This is the first report highlighting a potential endocrine role for DUX4. |
| format |
Artículo Artículo |
| author |
Quintero, Julieta Saad, Nizar Y. Pagnoni, Sabrina M. Jacquelin, Daniela K. Gatica, Laura V. Harper, Scott Q. Rosa, Alberto Luis dir. |
| author_facet |
Quintero, Julieta Saad, Nizar Y. Pagnoni, Sabrina M. Jacquelin, Daniela K. Gatica, Laura V. Harper, Scott Q. Rosa, Alberto Luis dir. |
| author_sort |
Quintero, Julieta |
| title |
The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| title_short |
The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| title_full |
The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| title_fullStr |
The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| title_full_unstemmed |
The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| title_sort |
dux4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors |
| publisher |
Wiley-Blackwell |
| publishDate |
2022 |
| url |
http://pa.bibdigital.ucc.edu.ar/3210/1/A_Quintero_Pagnoni_Jacquelin.pdf |
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