Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae

The anti-inflammatory activity of the petroleum ether, dichloromethane and methanol extracts from Heterotheca subaxillaris var. latifolia were assayed using 12-O-tetradecanoyl phorbol acetate (TPA) induced ear edema test in mice and carrageenan-induced paw edema test in rats. The dichloromethane ext...

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Autores principales: Gorzalczany, Susana, Rosella, Maria A., Spegazzini, Etile D., Acevedo, Cristina, Debenedetti, Silvia L.
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Proyectos de Investigación 2014
Materias:
Heterotheca subaxillaris var. latifolia
Asteraceae
anti-inflammatory activity
flavonoids
Actividad anti-inflamatoria
Flavonoides
Acceso en línea:http://repositorio.ub.edu.ar/handle/123456789/2706
Aporte de:
Repositorio Institucional - Universidad de Belgrano (UB) de Universidad de Belgrano
id I36-R142-123456789-2706
record_format dspace
institution Universidad de Belgrano
institution_str I-36
repository_str R-142
collection Repositorio Institucional - Universidad de Belgrano (UB)
language Inglés
topic Heterotheca subaxillaris var. latifolia
Asteraceae
anti-inflammatory activity
flavonoids
Actividad anti-inflamatoria
Flavonoides
spellingShingle Heterotheca subaxillaris var. latifolia
Asteraceae
anti-inflammatory activity
flavonoids
Actividad anti-inflamatoria
Flavonoides
Gorzalczany, Susana
Rosella, Maria A.
Spegazzini, Etile D.
Acevedo, Cristina
Debenedetti, Silvia L.
Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
topic_facet Heterotheca subaxillaris var. latifolia
Asteraceae
anti-inflammatory activity
flavonoids
Actividad anti-inflamatoria
Flavonoides
description The anti-inflammatory activity of the petroleum ether, dichloromethane and methanol extracts from Heterotheca subaxillaris var. latifolia were assayed using 12-O-tetradecanoyl phorbol acetate (TPA) induced ear edema test in mice and carrageenan-induced paw edema test in rats. The dichloromethane extract showed a significant anti-inflammatory activity (91% of inhibition) in TPA-induced ear edema test (topical administration at 1 mg/ear). No effects were seen on carragenan-induced edema. Bio-guided fractionation deal to the isolation of the major flavonoids santin, pectolinaringenin, 3,6-dimethoxy-5,7,4'-trihydroxyflavone and hispidulin present in the active fractions.
format Article
author Gorzalczany, Susana
Rosella, Maria A.
Spegazzini, Etile D.
Acevedo, Cristina
Debenedetti, Silvia L.
author_facet Gorzalczany, Susana
Rosella, Maria A.
Spegazzini, Etile D.
Acevedo, Cristina
Debenedetti, Silvia L.
author_sort Gorzalczany, Susana
title Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
title_short Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
title_full Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
title_fullStr Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
title_full_unstemmed Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae
title_sort anti-inflammatory activity of heterotheca subaxillaris var. latifolia (buckley) gandhi & r.d. thomas, asteraceae
publisher Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Proyectos de Investigación
publishDate 2014
url http://repositorio.ub.edu.ar/handle/123456789/2706
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