The chloride anion as a signalling effector
Abstract: The specific role of the chloride anion (Cl- ) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functi...
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Formato: | Artículo |
Lenguaje: | Inglés |
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Wiley
2020
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Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/9737 |
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I33-R139123456789-9737 |
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institution |
Universidad Católica Argentina |
institution_str |
I-33 |
repository_str |
R-139 |
collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
language |
Inglés |
topic |
TRANSDUCCION DE SEÑAL CFTR ANION CLORURO INFLAMACION ESTRES OXIDATIVO SEÑALIZACION INTRACELULAR |
spellingShingle |
TRANSDUCCION DE SEÑAL CFTR ANION CLORURO INFLAMACION ESTRES OXIDATIVO SEÑALIZACION INTRACELULAR Valdivieso, Ángel Gabriel Santa Coloma, Tomás Antonio The chloride anion as a signalling effector |
topic_facet |
TRANSDUCCION DE SEÑAL CFTR ANION CLORURO INFLAMACION ESTRES OXIDATIVO SEÑALIZACION INTRACELULAR |
description |
Abstract: The specific role of the chloride anion (Cl- ) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functions such as gene and protein expression and activities, post-translational modifications of proteins, cellular volume, cell cycle, cell proliferation and differentiation, membrane potential, reactive oxygen species levels, and intracellular/extracellular pH. Cl- also modulates functions in different organelles, including endosomes, phagosomes, lysosomes, endoplasmic reticulum, and mitochondria. A better knowledge of Cl- signalling could help in understanding the molecular and metabolic changes seen in pathologies with altered Cl- transport or under physiological conditions. Here we review relevant evidence supporting the role of Cl- as a signalling effector. |
format |
Artículo |
author |
Valdivieso, Ángel Gabriel Santa Coloma, Tomás Antonio |
author_facet |
Valdivieso, Ángel Gabriel Santa Coloma, Tomás Antonio |
author_sort |
Valdivieso, Ángel Gabriel |
title |
The chloride anion as a signalling effector |
title_short |
The chloride anion as a signalling effector |
title_full |
The chloride anion as a signalling effector |
title_fullStr |
The chloride anion as a signalling effector |
title_full_unstemmed |
The chloride anion as a signalling effector |
title_sort |
chloride anion as a signalling effector |
publisher |
Wiley |
publishDate |
2020 |
url |
https://repositorio.uca.edu.ar/handle/123456789/9737 |
work_keys_str_mv |
AT valdiviesoangelgabriel thechlorideanionasasignallingeffector AT santacolomatomasantonio thechlorideanionasasignallingeffector AT valdiviesoangelgabriel chlorideanionasasignallingeffector AT santacolomatomasantonio chlorideanionasasignallingeffector |
bdutipo_str |
Repositorios |
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1764820528522067968 |