An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn

Abstract: Hypoxic-ischemic encephalopathy (HIE) is one of the most frequent causes of brain injury in the newborn. From a pathophysiological standpoint, a complex process takes place at the cellular and tissue level during the development of newborn brain damage in the absence of oxygen. Initially,...

Descripción completa

Detalles Bibliográficos
Autor principal: Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2020
Materias:
APOPTOSIS
MELATONINA
NEURODEGENERACION
ESTRES OXIDATIVO
HIPOTERMIA
ENCEFALOPATIAS
ISQUEMIA ENCEFALICA
ANTIOXIDANTES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9646
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9646
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic APOPTOSIS
MELATONINA
NEURODEGENERACION
ESTRES OXIDATIVO
HIPOTERMIA
ENCEFALOPATIAS
ISQUEMIA ENCEFALICA
ANTIOXIDANTES
spellingShingle APOPTOSIS
MELATONINA
NEURODEGENERACION
ESTRES OXIDATIVO
HIPOTERMIA
ENCEFALOPATIAS
ISQUEMIA ENCEFALICA
ANTIOXIDANTES
Cardinali, Daniel Pedro
An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
topic_facet APOPTOSIS
MELATONINA
NEURODEGENERACION
ESTRES OXIDATIVO
HIPOTERMIA
ENCEFALOPATIAS
ISQUEMIA ENCEFALICA
ANTIOXIDANTES
description Abstract: Hypoxic-ischemic encephalopathy (HIE) is one of the most frequent causes of brain injury in the newborn. From a pathophysiological standpoint, a complex process takes place at the cellular and tissue level during the development of newborn brain damage in the absence of oxygen. Initially, the lesion is triggered by a deficit in the supply of oxygen to cells and tissues, causing a primary energy insufficiency. Subsequently, high energy phosphate levels recover transiently (the latent phase) that is followed by a secondary phase, in which many of the pathophysiological mechanisms involved in the development of neonatal brain damage ensue (i.e., excitotoxicity, massive influx of Ca2+, oxidative and nitrosative stress, inflammation). This leads to cell death by necrosis or apoptosis. Eventually, a tertiary phase occurs, characterized by the persistence of brain damage for months and even years after the HI insult. Hypothermia is the only therapeutic strategy against HIE that has been incorporated into neonatal intensive care units with limited success. Thus, there is an urgent need for agents with the capacity to curtail acute and chronic damage in HIE. Melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, has a potential role as a neuroprotective agent both acutely and chronically in HIE. Melatonin displays a remarkable antioxidant and anti-inflammatory activity and is capable to cross the blood-brain barrier readily. Moreover, in many animal models of brain degeneration, melatonin was effective to impair chronic mechanisms of neuronal death. In animal models, and in a limited number of clinical studies, melatonin increased the level of protection developed by hypothermia in newborn asphyxia. This review article summarizes briefly the available therapeutic strategies in HIE and assesses the role of melatonin as a potentially relevant therapeutic tool to cover the hypoxia-ischemia phase and the secondary and tertiary phases following a hypoxic-ischemic insult.
format Artículo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_sort Cardinali, Daniel Pedro
title An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
title_short An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
title_full An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
title_fullStr An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
title_full_unstemmed An assessment of melatonin's therapeutic value in the hypoxic-Ischemic encephalopathy of the newborn
title_sort assessment of melatonin's therapeutic value in the hypoxic-ischemic encephalopathy of the newborn
publisher Frontiers Media
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9646
work_keys_str_mv AT cardinalidanielpedro anassessmentofmelatoninstherapeuticvalueinthehypoxicischemicencephalopathyofthenewborn
AT cardinalidanielpedro assessmentofmelatoninstherapeuticvalueinthehypoxicischemicencephalopathyofthenewborn
bdutipo_str Repositorios
_version_ 1764820528413016064

Ejemplares similares