TRPC channels are not required for graded persistent activity in entorhinal cortex neurons

Abstract: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be generated by cell-autonomous biophysical properties of neurons or/and...

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Detalles Bibliográficos
Autores principales: Egorov, Alexei V., Schumacher, Dagmar, Medert, Rebekka, Birnbaumer, Lutz, Freichel, Marc, Draguhn, Andreas
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2020
Materias:
FUNCION COGNITIVA
NEURONAS
CORTEZA CEREBRAL
NEUROTRANSMISORES
MEMORIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9470
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9470
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic FUNCION COGNITIVA
NEURONAS
CORTEZA CEREBRAL
NEUROTRANSMISORES
MEMORIA
spellingShingle FUNCION COGNITIVA
NEURONAS
CORTEZA CEREBRAL
NEUROTRANSMISORES
MEMORIA
Egorov, Alexei V.
Schumacher, Dagmar
Medert, Rebekka
Birnbaumer, Lutz
Freichel, Marc
Draguhn, Andreas
TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
topic_facet FUNCION COGNITIVA
NEURONAS
CORTEZA CEREBRAL
NEUROTRANSMISORES
MEMORIA
description Abstract: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be generated by cell-autonomous biophysical properties of neurons or/and neural circuit dynamics. A number of studies from brain slices reports intrinsically generated persistent firing in cortical excitatory neurons following suprathreshold depolarization by intracellular current injection. In layer V (LV) neurons of the medial entorhinal cortex (mEC) persistent firing depends on the activation of cholinergic muscarinic receptors and is mediated by a calcium-activated nonselective cation current (ICAN ). The molecular identity of this conductance remains, however, unknown. Recently, it has been suggested that the underlying ion channels belong to the canonical transient receptor potential (TRPC) channel family and include heterotetramers of TRPC1/5, TRPC1/4, and/or TRPC1/4/5 channels. While this suggestion was based on pharmacological experiments and on effects of TRP-interacting peptides, an unambiguous proof based on TRPC channel-depleted animals is pending. Here, we used two different lines of TRPC channel knockout mice, either lacking TRPC1-, TRPC4-, and TRPC5-containing channels or lacking all seven members of the TRPC family. We report unchanged persistent activity in mEC LV neurons in these animals, ruling out that muscarinic-dependent persistent activity depends on TRPC channels.
format Artículo
author Egorov, Alexei V.
Schumacher, Dagmar
Medert, Rebekka
Birnbaumer, Lutz
Freichel, Marc
Draguhn, Andreas
author_facet Egorov, Alexei V.
Schumacher, Dagmar
Medert, Rebekka
Birnbaumer, Lutz
Freichel, Marc
Draguhn, Andreas
author_sort Egorov, Alexei V.
title TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
title_short TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
title_full TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
title_fullStr TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
title_full_unstemmed TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
title_sort trpc channels are not required for graded persistent activity in entorhinal cortex neurons
publisher Wiley
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9470
work_keys_str_mv AT egorovalexeiv trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
AT schumacherdagmar trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
AT medertrebekka trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
AT birnbaumerlutz trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
AT freichelmarc trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
AT draguhnandreas trpcchannelsarenotrequiredforgradedpersistentactivityinentorhinalcortexneurons
bdutipo_str Repositorios
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