Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin

Abstract: Alzheimer’s disease (AD) is associated with altered eating behavior and metabolic disruption. Amyloid plaques and neurofilament tangles are observed in many hypothalamic nuclei from AD brains. Some of these areas (suprachiasmatic nuclei, lateral hypothalamic area) also play a role in the...

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Detalles Bibliográficos
Autores principales: Spinedi, Eduardo J., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Karger 2019
Materias:
MELATONINA
ENFERMEDAD DE ALZHEIMER
INSULINA
CRONOBIOLOGIA
ALIMENTACIÓN
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9108
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9108
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
ENFERMEDAD DE ALZHEIMER
INSULINA
CRONOBIOLOGIA
ALIMENTACIÓN
spellingShingle MELATONINA
ENFERMEDAD DE ALZHEIMER
INSULINA
CRONOBIOLOGIA
ALIMENTACIÓN
Spinedi, Eduardo J.
Cardinali, Daniel Pedro
Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
topic_facet MELATONINA
ENFERMEDAD DE ALZHEIMER
INSULINA
CRONOBIOLOGIA
ALIMENTACIÓN
description Abstract: Alzheimer’s disease (AD) is associated with altered eating behavior and metabolic disruption. Amyloid plaques and neurofilament tangles are observed in many hypothalamic nuclei from AD brains. Some of these areas (suprachiasmatic nuclei, lateral hypothalamic area) also play a role in the regulation of the sleep/wake cycle and may explain the comorbidity of eating and sleep disorders observed in AD patients. Inadequate sleep increases the neurodegenerative process, for example, the decrease of slow-wave sleep impairs clearance of β-amyloid peptide (Aβ) and tau protein from cerebral interstitial fluid. Cerebrospinal fluid (CSF) melatonin levels decrease even in preclinical stages (Braak-1 stage) when patients manifest no cognitive impairment, suggesting that reduction of melatonin in CSF may be an early marker (the cause for which is still unknown) of oncoming AD. Melatonin administration augments glymphatic clearance of Aβ and reduces generation and deposition of Aβ in transgenic animal models of AD. It may also set up a new equilibrium among hypothalamic feeding signals. While melatonin trials performed in the clinical phase of AD have failed to show or showed only modest positive effects on cognition, in the preclinical stage of dementia (minimal cognitive impairment)the effect of melatonin is demonstrable with significant improvement of sleep and quality of life. In this review, we discuss the main aspects of hypothalamic alterations in AD, the association between interrupted sleep and neurodegeneration, and the possible therapeutic effect of melatonin on these processes.
format Artículo
author Spinedi, Eduardo J.
Cardinali, Daniel Pedro
author_facet Spinedi, Eduardo J.
Cardinali, Daniel Pedro
author_sort Spinedi, Eduardo J.
title Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
title_short Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
title_full Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
title_fullStr Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
title_full_unstemmed Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin
title_sort neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on alzheimer's disease and melatonin
publisher Karger
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/9108
work_keys_str_mv AT spinedieduardoj neuroendocrinemetabolicdysfunctionandsleepdisturbancesinneurodegenerativedisordersfocusonalzheimersdiseaseandmelatonin
AT cardinalidanielpedro neuroendocrinemetabolicdysfunctionandsleepdisturbancesinneurodegenerativedisordersfocusonalzheimersdiseaseandmelatonin
bdutipo_str Repositorios
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