Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?

Abstract: Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfuncti...

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Detalles Bibliográficos
Autores principales: Di Rosso, María Emilia, Palumbo, María Laura, Genaro, Ana María
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
ANTIDEPRESIVOS
DEPRESION
SISTEMA INMUNOLOGICO
SEROTONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8782
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8782
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ANTIDEPRESIVOS
DEPRESION
SISTEMA INMUNOLOGICO
SEROTONINA
spellingShingle ANTIDEPRESIVOS
DEPRESION
SISTEMA INMUNOLOGICO
SEROTONINA
Di Rosso, María Emilia
Palumbo, María Laura
Genaro, Ana María
Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
topic_facet ANTIDEPRESIVOS
DEPRESION
SISTEMA INMUNOLOGICO
SEROTONINA
description Abstract: Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, there is contradictory evidence about the effect of fluoxetine on the immune system. Experimental findings indicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetine is able to modulate the immune function through a serotonin-dependent pathway and through a novel independent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cell viability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumor growth by increasing antitumor T-cell activity. Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better or worse, the functionality of the immune system. These results of our analysis point to the relevance of the novel pharmacological action of this drug as an immunomodulator helping to treat several pathologies in which immune deficiency and/or deregulation is present.
format Artículo
author Di Rosso, María Emilia
Palumbo, María Laura
Genaro, Ana María
author_facet Di Rosso, María Emilia
Palumbo, María Laura
Genaro, Ana María
author_sort Di Rosso, María Emilia
title Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
title_short Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
title_full Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
title_fullStr Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
title_full_unstemmed Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
title_sort immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8782
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AT palumbomarialaura immunomodulatoryeffectsoffluoxetineanewpotentialpharmacologicalactionforaclassicantidepressantdrug
AT genaroanamaria immunomodulatoryeffectsoffluoxetineanewpotentialpharmacologicalactionforaclassicantidepressantdrug
bdutipo_str Repositorios
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