Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice

Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in...

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Autores principales: Choi, Jung-Mi, Kim, Sung-Soo, Choi, Chan-Il, Cha, Hye Lim, Oh, Huy-Hyen, Ghil, Sungho, Lee, Young-Don, Birnbaumer, Lutz, Suh-Kim, Haeyoung
Formato: Artículo
Lenguaje:Inglés
Publicado: National Academy of Sciences 2019
Materias:
PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8760
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8760
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
spellingShingle PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
Choi, Jung-Mi
Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
topic_facet PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
description Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.
format Artículo
author Choi, Jung-Mi
Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author_facet Choi, Jung-Mi
Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author_sort Choi, Jung-Mi
title Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_short Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_full Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_fullStr Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_full_unstemmed Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_sort development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in go-deficient mice
publisher National Academy of Sciences
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8760
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