Does erythropoietin regulate TRPC channels in red blood cells?

Abstract: Cation channels play an essential role in red blood cells (RBCs) ion homeostasis. One set of ion channels are the transient receptor potential channels of canonical type (TRPC channels). The abundance of these channels in primary erythroblasts, erythroid cell lines and RBCs was associated...

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Detalles Bibliográficos
Autores principales: Danielczok, Jens, Hertz, Laura, Ruppenthal, Sandra, Kaiser, Elisabeth, Petkova-Kirova, Polina, Bogdanova, Anna, Krause, Elmar, Lipp, Peter, Freichel, Marc, Kaestner, Lars, Birnbaumer, Lutz
Formato: Artículo
Lenguaje:Inglés
Publicado: Karger Publishers 2019
Materias:
GLOBULOS ROJOS
METABOLISMO
CALCIO
CELULAS
SANGRE
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8729
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
Descripción
Sumario:Abstract: Cation channels play an essential role in red blood cells (RBCs) ion homeostasis. One set of ion channels are the transient receptor potential channels of canonical type (TRPC channels). The abundance of these channels in primary erythroblasts, erythroid cell lines and RBCs was associated with an increase in intracellular Ca2+ upon stimulation with Erythropoietin (Epo). In contrast two independent studies on Epo-treated patients revealed diminished basal Ca2+ concentration or reduced phosphatidylserine exposure to the outer membrane leaflet.

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