Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models

Abstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided int...

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Autores principales: Martinel Lamas, Diego J., Nicoud, Melisa Beatriz, Sterle, Helena Andrea, Carabajal, Eliana, Tesan, Fiorella C., Perazzo, Juan C., Cremaschi, Graciela A., Rivera, Elena S., Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: Nature Research 2019
Materias:
MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8706
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8706
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
spellingShingle MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
Martinel Lamas, Diego J.
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
topic_facet MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
description Abstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5mg/kg for rats and 1mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
format Artículo
author Martinel Lamas, Diego J.
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
author_facet Martinel Lamas, Diego J.
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
author_sort Martinel Lamas, Diego J.
title Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_short Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_fullStr Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full_unstemmed Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_sort selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
publisher Nature Research
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8706
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