Fatty acid regulation of voltage-and-ligand-gated ion channel function

Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to...

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Detalles Bibliográficos
Autores principales: Antollini, Silvia S., Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2019
Materias:
MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8689
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8689
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
spellingShingle MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
Antollini, Silvia S.
Barrantes, Francisco José
Fatty acid regulation of voltage-and-ligand-gated ion channel function
topic_facet MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
description Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.
format Artículo
author Antollini, Silvia S.
Barrantes, Francisco José
author_facet Antollini, Silvia S.
Barrantes, Francisco José
author_sort Antollini, Silvia S.
title Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_short Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_full Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_fullStr Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_full_unstemmed Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_sort fatty acid regulation of voltage-and-ligand-gated ion channel function
publisher Frontiers
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8689
work_keys_str_mv AT antollinisilvias fattyacidregulationofvoltageandligandgatedionchannelfunction
AT barrantesfranciscojose fattyacidregulationofvoltageandligandgatedionchannelfunction
bdutipo_str Repositorios
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