Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine...

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Autores principales: Dieguez, Hernán H., Romeo, Horacio, González Fleitas, María F., Aranda, Marcos L., Milne, Georgia A., Rosenstein, Ruth E., Dorfman, Damián
Formato: Artículo
Lenguaje:Inglés
Publicado: Company of Biologists 2019
Materias:
DEGENERACION MACULAR
GANGLIOS
RETINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8621
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8621
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic DEGENERACION MACULAR
GANGLIOS
RETINA
spellingShingle DEGENERACION MACULAR
GANGLIOS
RETINA
Dieguez, Hernán H.
Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
topic_facet DEGENERACION MACULAR
GANGLIOS
RETINA
description Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.
format Artículo
author Dieguez, Hernán H.
Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
author_facet Dieguez, Hernán H.
Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
author_sort Dieguez, Hernán H.
title Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_short Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_full Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_fullStr Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_full_unstemmed Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_sort superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
publisher Company of Biologists
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8621
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