New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

Abstract: The immune system acts on different metabolic tissues that are implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Leptin and linoleic acid have the ability to potentially affect immune cells, whereas curcumin is a known natural polyphenol with antioxidant and anti-...

Descripción completa

Detalles Bibliográficos
Autores principales: Inzaugarat, María Eugenia, De Matteo, Elena, Baz, Placida, Lucero, Diego, García, Cecilia Claudia, González Ballerga, Esteban, Daruich, Jorge, Sorda, Juan Antonio, Wald, Miriam Ruth, Cherñavsky, Alejandra Claudia
Formato: Artículo
Lenguaje:Inglés
Publicado: PLOS 2019
Materias:
MEDICINA
LEPTINA
ACIDO LINOLEICO
CURCUMINA
ENFERMEDADES HEPATICAS
HIGADO GRASO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8528
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172900
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8528
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
LEPTINA
ACIDO LINOLEICO
CURCUMINA
ENFERMEDADES HEPATICAS
HIGADO GRASO
spellingShingle MEDICINA
LEPTINA
ACIDO LINOLEICO
CURCUMINA
ENFERMEDADES HEPATICAS
HIGADO GRASO
Inzaugarat, María Eugenia
De Matteo, Elena
Baz, Placida
Lucero, Diego
García, Cecilia Claudia
González Ballerga, Esteban
Daruich, Jorge
Sorda, Juan Antonio
Wald, Miriam Ruth
Cherñavsky, Alejandra Claudia
New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
topic_facet MEDICINA
LEPTINA
ACIDO LINOLEICO
CURCUMINA
ENFERMEDADES HEPATICAS
HIGADO GRASO
description Abstract: The immune system acts on different metabolic tissues that are implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Leptin and linoleic acid have the ability to potentially affect immune cells, whereas curcumin is a known natural polyphenol with antioxidant and anti-inflammatory properties. This study was designed to evaluate the pro-inflammatory and pro-oxidant effects of leptin and linoleic acid on immune cells from patients with NAFLD and to corroborate the modulatory effects of curcumin and its preventive properties against the progression of NAFLD using a high-fat diet (HFD)-induced NAFLD/nonalcoholic steatohepatitis mouse model. The ex vivo experiments showed that linoleic acid increased the production of reactive oxygen species in monocytes and liver macrophages, whereas leptin enhanced tumor necrosis factor-α (TNF-α) production in monocytes and interferon-γ production in circulating CD4 cells. Conversely, oral administration of curcumin prevented HFD-induced liver injury, metabolic alterations, intrahepatic CD4 cell accumulation and the linoleic acid- and leptin- induced pro-inflammatory and pro-oxidant effects on mouse liver macrophages. ur findings provide new evidence for the therapeutic potential of curcumin to treat human NAFLD. However, the development of a preventive treatment targeting human circulating monocytes and liver macrophages as well as peripheral and hepatic CD4 cells requires additional research.
format Artículo
author Inzaugarat, María Eugenia
De Matteo, Elena
Baz, Placida
Lucero, Diego
García, Cecilia Claudia
González Ballerga, Esteban
Daruich, Jorge
Sorda, Juan Antonio
Wald, Miriam Ruth
Cherñavsky, Alejandra Claudia
author_facet Inzaugarat, María Eugenia
De Matteo, Elena
Baz, Placida
Lucero, Diego
García, Cecilia Claudia
González Ballerga, Esteban
Daruich, Jorge
Sorda, Juan Antonio
Wald, Miriam Ruth
Cherñavsky, Alejandra Claudia
author_sort Inzaugarat, María Eugenia
title New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
title_short New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
title_full New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
title_fullStr New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
title_full_unstemmed New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
title_sort new evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans
publisher PLOS
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8528
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172900
work_keys_str_mv AT inzaugaratmariaeugenia newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT dematteoelena newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT bazplacida newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT lucerodiego newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT garciaceciliaclaudia newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT gonzalezballergaesteban newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT daruichjorge newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT sordajuanantonio newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT waldmiriamruth newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
AT chernavskyalejandraclaudia newevidenceforthetherapeuticpotentialofcurcumintotreatnonalcoholicfattyliverdiseaseinhumans
bdutipo_str Repositorios
_version_ 1764820528238952449

Ejemplares similares