Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis

Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient ant...

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Autores principales: Rosenstein, Ruth E., Pandi Perumal, Seithikurippu R., Srinivasan, Venkataramanujan, Spence, David Warren, Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: 2019
Materias:
MELATONINA
OFTALMOLOGIA
RECEPTORES DE MELATONINA
ESTRES OXIDATIVO
OJOS
GLAUCOMA
UVEITIS
APLICACIONES TERAPEUTICAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1666
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1666
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
OFTALMOLOGIA
RECEPTORES DE MELATONINA
ESTRES OXIDATIVO
OJOS
GLAUCOMA
UVEITIS
APLICACIONES TERAPEUTICAS
spellingShingle MELATONINA
OFTALMOLOGIA
RECEPTORES DE MELATONINA
ESTRES OXIDATIVO
OJOS
GLAUCOMA
UVEITIS
APLICACIONES TERAPEUTICAS
Rosenstein, Ruth E.
Pandi Perumal, Seithikurippu R.
Srinivasan, Venkataramanujan
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
topic_facet MELATONINA
OFTALMOLOGIA
RECEPTORES DE MELATONINA
ESTRES OXIDATIVO
OJOS
GLAUCOMA
UVEITIS
APLICACIONES TERAPEUTICAS
description Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye.
format Artículo
author Rosenstein, Ruth E.
Pandi Perumal, Seithikurippu R.
Srinivasan, Venkataramanujan
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Rosenstein, Ruth E.
Pandi Perumal, Seithikurippu R.
Srinivasan, Venkataramanujan
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Rosenstein, Ruth E.
title Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
title_short Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
title_full Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
title_fullStr Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
title_full_unstemmed Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
title_sort melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1666
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