The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease

Abstract: Treatment of circadian rhythm disorders, whether precipitated by intrinsic factors (e.g., sleep disorders, blindness, mental disorders, aging) or by extrinsic factors (e.g., shift work, jet-lag) has led to the development of a new type of agents called “chronobiotics”. The term “chronobiot...

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Autores principales: Cardinali, Daniel Pedro, Furio, Analía M., Brusco, Luis I.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Bentham Science 2019
Materias:
ENFERMEDAD DE ALZHEIMER
RITMO CIRCADIANO
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1661
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1661
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic ENFERMEDAD DE ALZHEIMER
RITMO CIRCADIANO
MELATONINA
spellingShingle ENFERMEDAD DE ALZHEIMER
RITMO CIRCADIANO
MELATONINA
Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
topic_facet ENFERMEDAD DE ALZHEIMER
RITMO CIRCADIANO
MELATONINA
description Abstract: Treatment of circadian rhythm disorders, whether precipitated by intrinsic factors (e.g., sleep disorders, blindness, mental disorders, aging) or by extrinsic factors (e.g., shift work, jet-lag) has led to the development of a new type of agents called “chronobiotics”. The term “chronobiotic” defines a substance displaying the therapeutic activity of shifting the phase or increasing the amplitude of the circadian rhythms. The prototype of this therapeutic group is melatonin, whose administration synchronizes the sleep-wake cycle in blind people and in individuals suffering from circadian rhythm sleep disorders, like delayed sleep phase syndrome, jet lag or shift-work. Daily melatonin production decreases with age, and in several pathologies, attaining its lowest values in Alzheimer’s disease (AD) patients. About half of dementia patients have severe disruptions in their sleepwakefulness cycle. Melatonin replacement is effective to treat sundowning and other sleep wake disorders in fully developed AD, although controversial data on this point exist. Indeed, large interindividual differences between patients suffering from AD exist and can explain these erratic results. Theoretically the effect of melatonin could be more consistent at an earlier stage of the disease, i.e., mild cognitive impairment (MCI), an etiologically heterogeneous syndrome that precedes dementia. PubMed was searched using Entrez for articles including clinical trials. Search terms were “Alzheimer” “mild cognitive impairment” and “melatonin”. Full publications were obtained and references were checked for additional material where appropriate. Only clinical studies with empirical treatment data were reviewed. Five double blind, randomized placebo controlled trials and 1 open label retrospective study (N= 651) all agree in indicating that treatment with daily evening melatonin improves sleep quality and cognitive performance in MCI. The analysis of published evidence and patents indicates that melatonin can be a useful ad-on therapeutic tool in the early phases of AD.
format Artículo
author Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
author_facet Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
author_sort Cardinali, Daniel Pedro
title The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
title_short The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
title_full The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
title_fullStr The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
title_full_unstemmed The use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of Alzheimer's disease
title_sort use of chronobiotics in the resynchronization of the sleep/wake cycle : therapeutical application in the early phases of alzheimer's disease
publisher Bentham Science
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1661
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