Melatonin in mitochondrial dysfunction and related disorders

Abstract: Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson’s disease (PD), Alzheimer’s disease (AD), and Huntington’s disease (HD). Increased free radical generati...

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Autores principales: Srinivasan, Venkataramanujan, Spence, David Warren, Pandi Perumal, Seithikurippu R., Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Hindawi 2019
Materias:
MELATONINA
RECEPTORES DE MELATONINA
FUNCION MITOCONDRIAL
ENFERMEDADES NEUROGENERATIVAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1656
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1656
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
RECEPTORES DE MELATONINA
FUNCION MITOCONDRIAL
ENFERMEDADES NEUROGENERATIVAS
spellingShingle MELATONINA
RECEPTORES DE MELATONINA
FUNCION MITOCONDRIAL
ENFERMEDADES NEUROGENERATIVAS
Srinivasan, Venkataramanujan
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
Melatonin in mitochondrial dysfunction and related disorders
topic_facet MELATONINA
RECEPTORES DE MELATONINA
FUNCION MITOCONDRIAL
ENFERMEDADES NEUROGENERATIVAS
description Abstract: Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson’s disease (PD), Alzheimer’s disease (AD), and Huntington’s disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhancedNOproduction, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
format Artículo
author Srinivasan, Venkataramanujan
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Srinivasan, Venkataramanujan
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Srinivasan, Venkataramanujan
title Melatonin in mitochondrial dysfunction and related disorders
title_short Melatonin in mitochondrial dysfunction and related disorders
title_full Melatonin in mitochondrial dysfunction and related disorders
title_fullStr Melatonin in mitochondrial dysfunction and related disorders
title_full_unstemmed Melatonin in mitochondrial dysfunction and related disorders
title_sort melatonin in mitochondrial dysfunction and related disorders
publisher Hindawi
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1656
work_keys_str_mv AT srinivasanvenkataramanujan melatonininmitochondrialdysfunctionandrelateddisorders
AT spencedavidwarren melatonininmitochondrialdysfunctionandrelateddisorders
AT pandiperumalseithikurippur melatonininmitochondrialdysfunctionandrelateddisorders
AT browngregorym melatonininmitochondrialdysfunctionandrelateddisorders
AT cardinalidanielpedro melatonininmitochondrialdysfunctionandrelateddisorders
bdutipo_str Repositorios
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