Potential use of melatonergic drugs in analgesia : mechanisms of action

abstract: Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirect scavenging of free radicals not involving receptors. Among melatonin´s many effects, its antinocice...

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Detalles Bibliográficos
Autores principales: Srinivasan, Venkataramanujan, Pandi Perumal, Seithikurippu R., Moscovitch, Adam, Spence, David Warren, Trakht, Ilya, Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
ANALGESIA
MELATONINA
RECEPTORES DE MELATONINA
NOCICEPTORES
RECEPTORES DE OPIOIDES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1633
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1633
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic ANALGESIA
MELATONINA
RECEPTORES DE MELATONINA
NOCICEPTORES
RECEPTORES DE OPIOIDES
spellingShingle ANALGESIA
MELATONINA
RECEPTORES DE MELATONINA
NOCICEPTORES
RECEPTORES DE OPIOIDES
Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Moscovitch, Adam
Spence, David Warren
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
Potential use of melatonergic drugs in analgesia : mechanisms of action
topic_facet ANALGESIA
MELATONINA
RECEPTORES DE MELATONINA
NOCICEPTORES
RECEPTORES DE OPIOIDES
description abstract: Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirect scavenging of free radicals not involving receptors. Among melatonin´s many effects, its antinociceptive actions have attracted attention. When given orally, intraperitoneally, locally, intrathecally or through intracerebroventricular routes, melatonin exerts antinociceptive and antiallodynic actions in a variety of animal models. These effects have been demonstrated in animal models of acute pain like the tail-flick test, formalin test or endotoxin-induced hyperalgesia as well as in models of neuropathic pain like nerve ligation. Glutamate, gamma-aminobutyric acid, and particularly, opioid neurotransmission have been demonstrated to be involved in melatonin´s analgesia. Results using melatonin receptor antagonists support the participation of melatonin receptors in melatonin´s analgesia. However, discrepancies between the affinity of the receptors and the very high doses of melatonin needed to cause effects in vivo raise doubts about the uniqueness of that physiopathological interpretation. Indeed, melatonin could play a role in pain through several alternative mechanisms including free radicals scavenging or nitric oxide synthase inhibition. The use of melatonin analogs like the MT1/MT2 agonist ramelteon, which lacks free radical scavenging activity, could be useful to unravel the mechanism of action of melatonin in analgesia. Melatonin has a promising role as an analgesic drug that could be used for alleviating pain associated with cancer, headache or surgical procedures.
format Artículo
author Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Moscovitch, Adam
Spence, David Warren
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Moscovitch, Adam
Spence, David Warren
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Srinivasan, Venkataramanujan
title Potential use of melatonergic drugs in analgesia : mechanisms of action
title_short Potential use of melatonergic drugs in analgesia : mechanisms of action
title_full Potential use of melatonergic drugs in analgesia : mechanisms of action
title_fullStr Potential use of melatonergic drugs in analgesia : mechanisms of action
title_full_unstemmed Potential use of melatonergic drugs in analgesia : mechanisms of action
title_sort potential use of melatonergic drugs in analgesia : mechanisms of action
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1633
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