Some implications of melatonin use in chronopharmacology of insomnia

Abstract: The last decade has witnessed the emergence of new chronopharmacological perspectives. In the case of sleep, accumulating evidence suggests that even a minor dysfunction in the biological clock can impact upon body physiology causing increases in sleep onset latency, phase delays or advanc...

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Detalles Bibliográficos
Autores principales: Golombek, Diego A., Pandi Perumal, Seithikurippu R., Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MEDICINA
RITMO CIRCADIANO
SUEÑO
MELATONINA
INSOMNIO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1459
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1459
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
RITMO CIRCADIANO
SUEÑO
MELATONINA
INSOMNIO
spellingShingle MEDICINA
RITMO CIRCADIANO
SUEÑO
MELATONINA
INSOMNIO
Golombek, Diego A.
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
Some implications of melatonin use in chronopharmacology of insomnia
topic_facet MEDICINA
RITMO CIRCADIANO
SUEÑO
MELATONINA
INSOMNIO
description Abstract: The last decade has witnessed the emergence of new chronopharmacological perspectives. In the case of sleep, accumulating evidence suggests that even a minor dysfunction in the biological clock can impact upon body physiology causing increases in sleep onset latency, phase delays or advances in sleep initiation, frequent nocturnal awakenings, reduced sleep efficiency, delayed and shortened rapid eye movement sleep and increased periodic leg movements. Thus, restoration of the adequate circadian pattern of by proper sleep hygiene, targeted exposure to light and the use of chronobiotic drugs, such as melatonin, which affect the output phase of clock-controlled circadian rhythms, can help to recover the sleep-wake cycle. The optimization of drug effects and/or minimization of toxicity by timing medications with regard to biological rhythms is known as chronotherapeutics. While chronotherapeutical approaches have been particularly successful in the treatment of hypertension, allergies and some forms of cancer, a time-dependent pharmacological approach can be also effective when dealing with sleep disruptions like insomnia. A large proportion of patients under benzodiazepine (BZD)/Z drug treatment fail to achieve a complete and sustained recovery and are left with residual symptoms, like tolerance or dependency, that make relapse or recurrence more likely, and poorer quality of life a reality. Thus the chronic and extensive use of BZD/Z drugs has become a public health issue and has led to multiple campaigns to reduce both prescription and consumption of BZD/Z-drugs. This short review discusses available data on the efficacy of melatonin to reduce chronic BZD use in insomnia patients.
format Artículo
author Golombek, Diego A.
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Golombek, Diego A.
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Golombek, Diego A.
title Some implications of melatonin use in chronopharmacology of insomnia
title_short Some implications of melatonin use in chronopharmacology of insomnia
title_full Some implications of melatonin use in chronopharmacology of insomnia
title_fullStr Some implications of melatonin use in chronopharmacology of insomnia
title_full_unstemmed Some implications of melatonin use in chronopharmacology of insomnia
title_sort some implications of melatonin use in chronopharmacology of insomnia
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1459
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