The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes

Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the...

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Autores principales: Valdivieso, Ángel Gabriel, Clauzure, Mariángeles, Massip Copiz, María Macarena, Santa Coloma, Tomás Antonio
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Karger International 2019
Materias:
GENETICA
BIOLOGIA CELULAR
CLORURO INTRACELULAR
FIBROSIS QUISTICA
BIOMEDICINA
SEGUNDO MENSAJERO
BIOLOGIA MOLECULAR
GENES CFTR DEPENDIENTES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1454
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1454
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic GENETICA
BIOLOGIA CELULAR
CLORURO INTRACELULAR
FIBROSIS QUISTICA
BIOMEDICINA
SEGUNDO MENSAJERO
BIOLOGIA MOLECULAR
GENES CFTR DEPENDIENTES
spellingShingle GENETICA
BIOLOGIA CELULAR
CLORURO INTRACELULAR
FIBROSIS QUISTICA
BIOMEDICINA
SEGUNDO MENSAJERO
BIOLOGIA MOLECULAR
GENES CFTR DEPENDIENTES
Valdivieso, Ángel Gabriel
Clauzure, Mariángeles
Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
topic_facet GENETICA
BIOLOGIA CELULAR
CLORURO INTRACELULAR
FIBROSIS QUISTICA
BIOMEDICINA
SEGUNDO MENSAJERO
BIOLOGIA MOLECULAR
GENES CFTR DEPENDIENTES
description Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR signalling mechanism involved in the expression of CFTRdependent genes is unknown. The aim of this work was to determine if intracellular chloride (Cl-Clconcentration, regulating in turn the expression of specific genes
format Artículo
author Valdivieso, Ángel Gabriel
Clauzure, Mariángeles
Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author_facet Valdivieso, Ángel Gabriel
Clauzure, Mariángeles
Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author_sort Valdivieso, Ángel Gabriel
title The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
title_short The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
title_full The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
title_fullStr The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
title_full_unstemmed The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
title_sort chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
publisher Karger International
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1454
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