Melatonin-induced oncostasis, mechanisms and clinical relevance

Abstract: Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or...

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Detalles Bibliográficos
Autores principales: Cardinali, Daniel Pedro, Escames, Germaine, Acuña Castroviejo, D., Ortiz, Francisco, Fernández Gil, Beatriz, Guerra Librero, Ana, García López, Sergio, Shen, Ying, Florido, Javier
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: OMICS International 2019
Materias:
BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1446
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1446
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
spellingShingle BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
Cardinali, Daniel Pedro
Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
Melatonin-induced oncostasis, mechanisms and clinical relevance
topic_facet BIOMEDICINA
MEDICINA
MELATONINA
CANCER
TUMORES
METASTASIS
APOPTOSIS
INMUNOLOGIA
description Abstract: Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors. The mechanisms involved include antiproliferative effects via modulation of cell cycle, ability to induce apoptosis in cancer cells, anti-angiogenic and antimetastatic effects, anti-estrogenic activity, the capacity to decrease telomerase activity, immune modulation, and direct and indirect antioxidant effects. Besides these oncostatic properties, melatonin deserves to be considered in the treatment of cancer for two other reasons. First, because its hypnotic-chronobiotic properties, melatonin use that can allow the clinician to effectively address sleep disturbances, a major co-morbidity in cancer. Second, because melatonin’s anxiolytic and antidepressant effects, it has a possible application in two other major co-morbidities seen in cancer patients, i.e. depression and anxiety. This report summarizes the possible mechanisms involved in melatonin oncostasis and reviews what is known about the clinical application of melatonin as an adjuvant therapy in cancer patients.
format Artículo
author Cardinali, Daniel Pedro
Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
author_facet Cardinali, Daniel Pedro
Escames, Germaine
Acuña Castroviejo, D.
Ortiz, Francisco
Fernández Gil, Beatriz
Guerra Librero, Ana
García López, Sergio
Shen, Ying
Florido, Javier
author_sort Cardinali, Daniel Pedro
title Melatonin-induced oncostasis, mechanisms and clinical relevance
title_short Melatonin-induced oncostasis, mechanisms and clinical relevance
title_full Melatonin-induced oncostasis, mechanisms and clinical relevance
title_fullStr Melatonin-induced oncostasis, mechanisms and clinical relevance
title_full_unstemmed Melatonin-induced oncostasis, mechanisms and clinical relevance
title_sort melatonin-induced oncostasis, mechanisms and clinical relevance
publisher OMICS International
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1446
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bdutipo_str Repositorios
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