Melatonin and brain inflammaging

Abstract: Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant. It is levels tend to decreas...

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Detalles Bibliográficos
Autores principales: Hardeland, Rüdiger, Cardinali, Daniel Pedro, Brown, Gregory M., Pandi Perumal, Seithikurippu R.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MEDICINA
MELATONINA
CEREBRO
INFLAMACION
MITOCONDRIA
ENFERMEDAD DE ALZHEIMER
ENVEJECIMIENTO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1442
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1442
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
MELATONINA
CEREBRO
INFLAMACION
MITOCONDRIA
ENFERMEDAD DE ALZHEIMER
ENVEJECIMIENTO
spellingShingle MEDICINA
MELATONINA
CEREBRO
INFLAMACION
MITOCONDRIA
ENFERMEDAD DE ALZHEIMER
ENVEJECIMIENTO
Hardeland, Rüdiger
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Melatonin and brain inflammaging
topic_facet MEDICINA
MELATONINA
CEREBRO
INFLAMACION
MITOCONDRIA
ENFERMEDAD DE ALZHEIMER
ENVEJECIMIENTO
description Abstract: Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant. It is levels tend to decrease in the course of senescence and are more strongly reduced in several neurodegenerative disorders, especially Alzheimer’s disease, and in diseases related to insulin resistance such as diabetes type 2. Although the role of melatonin in aging and age-related diseases has been repeatedly discussed, the newly emerged concept of inflammaging, that is, the contribution of low-grade inflammation to senescence progression has not yet been the focus of melatonin research. This review addresses the multiple protective actions of melatonin and its kynuramine metabolites that are relevant to the attenuation of inflammatory responses and progression of inflammaging in the brain, i.e. avoidance of excitotoxicity, reduction of free radical formation by support of mitochondrial electron flux, prevention of NADPH oxidase activation and suppression of inducible nitric oxide synthase, as well as downregulation of proinflammatory cytokines. The experimental evidence is primarily discussed on the basis of aging and senescence-accelerated animals, actions in the immune system, and the relationship between melatonin and sirtuins, having properties of aging suppressors. Sirtuins act either as accessory components or downstream factors of circadian oscillators, which are also under control by melatonin. Inflammaging is assumed to strongly contribute to neurodegeneration of the circadian master clock observed in advanced senescence and, even more, in Alzheimer’s disease, a change that affects countless physiological functions.
format Artículo
author Hardeland, Rüdiger
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_facet Hardeland, Rüdiger
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_sort Hardeland, Rüdiger
title Melatonin and brain inflammaging
title_short Melatonin and brain inflammaging
title_full Melatonin and brain inflammaging
title_fullStr Melatonin and brain inflammaging
title_full_unstemmed Melatonin and brain inflammaging
title_sort melatonin and brain inflammaging
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1442
work_keys_str_mv AT hardelandrudiger melatoninandbraininflammaging
AT cardinalidanielpedro melatoninandbraininflammaging
AT browngregorym melatoninandbraininflammaging
AT pandiperumalseithikurippur melatoninandbraininflammaging
bdutipo_str Repositorios
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