How membrane lipids control the 3D structure and function of receptors

Abstract: The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface o...

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Detalles Bibliográficos
Autores principales: Fantini, Jacques, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: AIMS Press 2019
Materias:
COLESTEROL
LIPIDOS
PROTEINAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1439
http://www.aimspress.com/article/10.3934/biophy.2018.1.22/fulltext.html
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1439
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic COLESTEROL
LIPIDOS
PROTEINAS
spellingShingle COLESTEROL
LIPIDOS
PROTEINAS
Fantini, Jacques
Barrantes, Francisco José
How membrane lipids control the 3D structure and function of receptors
topic_facet COLESTEROL
LIPIDOS
PROTEINAS
description Abstract: The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.
format Artículo
author Fantini, Jacques
Barrantes, Francisco José
author_facet Fantini, Jacques
Barrantes, Francisco José
author_sort Fantini, Jacques
title How membrane lipids control the 3D structure and function of receptors
title_short How membrane lipids control the 3D structure and function of receptors
title_full How membrane lipids control the 3D structure and function of receptors
title_fullStr How membrane lipids control the 3D structure and function of receptors
title_full_unstemmed How membrane lipids control the 3D structure and function of receptors
title_sort how membrane lipids control the 3d structure and function of receptors
publisher AIMS Press
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1439
http://www.aimspress.com/article/10.3934/biophy.2018.1.22/fulltext.html
work_keys_str_mv AT fantinijacques howmembranelipidscontrolthe3dstructureandfunctionofreceptors
AT barrantesfranciscojose howmembranelipidscontrolthe3dstructureandfunctionofreceptors
bdutipo_str Repositorios
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