Melatonin as an add-on treatment of COVID-19 infection : current status

Abstract: This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing the contrary, there has been great relu...

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Autores principales: Brown, Gregory M., Pandi Perumal, Seithikurippu R., Pupko, Harold, Kennedy, James L., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: MDPI 2022
Materias:
MELATONINA
COVID-19
INMUNIDAD
CITOCINAS
MITOCONDRIAS
ANTIOXIDANTES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13682
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13682
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
COVID-19
INMUNIDAD
CITOCINAS
MITOCONDRIAS
ANTIOXIDANTES
spellingShingle MELATONINA
COVID-19
INMUNIDAD
CITOCINAS
MITOCONDRIAS
ANTIOXIDANTES
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Pupko, Harold
Kennedy, James L.
Cardinali, Daniel Pedro
Melatonin as an add-on treatment of COVID-19 infection : current status
topic_facet MELATONINA
COVID-19
INMUNIDAD
CITOCINAS
MITOCONDRIAS
ANTIOXIDANTES
description Abstract: This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing the contrary, there has been great reluctance to conceive melatonin as anything other than a hormone. Many other body chemicals are known to have multiple roles. Melatonin was first shown to be a hormone derived from the pineal gland, to be actively synthesized there only at night, and to act on targets directly or via the G-proteincoupled receptors (GPCRs) superfamily. It is of note that over 40 years ago, it was also established that melatonin is present, synthesized locally, and acts within the gastrointestinal tract. A wider distribution was then found, including the retina and multiple body tissues. In addition, melatonin is now known to have non-hormonal actions, acting as a free radical scavenger, an antioxidant, and as modulating immunity, dampening down innate tissue responses to invaders while boosting the production of antibodies against them. These actions make it a potentially excellent weapon against infection by the SARS-CoV-2 virus. Early published results support that thesis. Recently, a randomized controlled study reported that low doses of melatonin significantly improved symptoms in hospitalized COVID-19 patients, leading to more rapid discharge with no side effects, while significantly decreasing levels of CRP, proinflammatory cytokines, and modulating dysregulated genes governing cellular and humoral immunity. It is now critical that these trials be repeated, with dose-response studies conducted and safety proven. Numerous randomized controlled trials are ongoing, which should complete those objectives while also allowing for a more thorough evaluation of the mechanisms of action and possible applications to other severe diseases.
format Artículo
author Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Pupko, Harold
Kennedy, James L.
Cardinali, Daniel Pedro
author_facet Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Pupko, Harold
Kennedy, James L.
Cardinali, Daniel Pedro
author_sort Brown, Gregory M.
title Melatonin as an add-on treatment of COVID-19 infection : current status
title_short Melatonin as an add-on treatment of COVID-19 infection : current status
title_full Melatonin as an add-on treatment of COVID-19 infection : current status
title_fullStr Melatonin as an add-on treatment of COVID-19 infection : current status
title_full_unstemmed Melatonin as an add-on treatment of COVID-19 infection : current status
title_sort melatonin as an add-on treatment of covid-19 infection : current status
publisher MDPI
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13682
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