Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration

Abstract: The association of age with a higher vulnerability to COVID-19 infection is a subject of major importance. Several factors, including higher stress due to social isolation, diminished melatonin levels with age, and higher exposure of individuals to light at the evening, which reduces melat...

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Autores principales: Cardinali, Daniel Pedro, Brown, Gregory M., Reiter, R., Pandi Perumal, Seithikurippu R.
Otros Autores: 0000-0002-0813-9088
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2022
Materias:
CRONOBIOLOGIA
RITMO CIRCADIANO
COVID-19
PANDEMIA
ADULTOS MAYORES
AISLAMIENTO SOCIAL, PREVENTIVO Y OBLIGATORIO
MELATONINA
SUEÑO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13638
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13638
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CRONOBIOLOGIA
RITMO CIRCADIANO
COVID-19
PANDEMIA
ADULTOS MAYORES
AISLAMIENTO SOCIAL, PREVENTIVO Y OBLIGATORIO
MELATONINA
SUEÑO
spellingShingle CRONOBIOLOGIA
RITMO CIRCADIANO
COVID-19
PANDEMIA
ADULTOS MAYORES
AISLAMIENTO SOCIAL, PREVENTIVO Y OBLIGATORIO
MELATONINA
SUEÑO
Cardinali, Daniel Pedro
Brown, Gregory M.
Reiter, R.
Pandi Perumal, Seithikurippu R.
Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
topic_facet CRONOBIOLOGIA
RITMO CIRCADIANO
COVID-19
PANDEMIA
ADULTOS MAYORES
AISLAMIENTO SOCIAL, PREVENTIVO Y OBLIGATORIO
MELATONINA
SUEÑO
description Abstract: The association of age with a higher vulnerability to COVID-19 infection is a subject of major importance. Several factors, including higher stress due to social isolation, diminished melatonin levels with age, and higher exposure of individuals to light at the evening, which reduces melatonin levels and disrupts circadian rhythmicity are relevant for maintaining the circadian health in aged individuals. Properly administered, chronotherapy restores the optimal circadian pattern of the sleep–wake cycle in the elderly. It involves adequate sleep hygiene, timed light exposure, and the use of a chronobiotic medication like melatonin, which affects the output phase of circadian rhythms thus controlling the biological clock. Besides, the therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections has been advocated due to its wide-ranging effects as an antioxidant, anti-inflammatory, and as an immunomodulatory agent, as well as to a possible antiviral action. This article discusses how chronotherapy may reverse the detrimental circadian condition of the elderly in the COVID-19 pandemic.
author2 0000-0002-0813-9088
author_facet 0000-0002-0813-9088
Cardinali, Daniel Pedro
Brown, Gregory M.
Reiter, R.
Pandi Perumal, Seithikurippu R.
format Artículo
author Cardinali, Daniel Pedro
Brown, Gregory M.
Reiter, R.
Pandi Perumal, Seithikurippu R.
author_sort Cardinali, Daniel Pedro
title Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
title_short Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
title_full Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
title_fullStr Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
title_full_unstemmed Elderly as a high‑risk group during COVID‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
title_sort elderly as a high‑risk group during covid‑19 pandemic : effect of circadian misalignment, sleep dysregulation and melatonin administration
publisher Springer
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13638
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