Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line

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Abstract: Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity...

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Autores principales: Martino, Renzo, Barreiro Arcos, María Laura, Peralta, Ignacio, Marrassini, Carla, Saint Martin, Elina Malén, Cogoi, Laura, Cremaschi, Graciela A., Alonso, María Rosario, Anesini, Claudia
Formato: Artículo
Lenguaje:Inglés
Publicado: Taylor and Francis 2021
Materias:
MELANOMA
FITOTERAPIA
APOPTOSIS
METASTASIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12861
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-12861
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELANOMA
FITOTERAPIA
APOPTOSIS
METASTASIS
spellingShingle MELANOMA
FITOTERAPIA
APOPTOSIS
METASTASIS
Martino, Renzo
Barreiro Arcos, María Laura
Peralta, Ignacio
Marrassini, Carla
Saint Martin, Elina Malén
Cogoi, Laura
Cremaschi, Graciela A.
Alonso, María Rosario
Anesini, Claudia
Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
topic_facet MELANOMA
FITOTERAPIA
APOPTOSIS
METASTASIS
description Abstract: Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity of the aqueous extract of Larrea divaricata (Aq), a fraction rich in polyphenols (EA),and the isolated compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. The effects of Aq, EA and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3. The phytochemical composition of the extracts was determined by High Performance Liquid Chromatography. Aq, EA and Q3ME presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late apoptosis induction (EC50 EA= ≤0.1 μg/ml; Aq= 316±30 μg/ml; Q3ME= <0.1 μg/ml). L. divaricata could be considered for the development of adjuvant phytotherapies in melanoma treatment.
format Artículo
author Martino, Renzo
Barreiro Arcos, María Laura
Peralta, Ignacio
Marrassini, Carla
Saint Martin, Elina Malén
Cogoi, Laura
Cremaschi, Graciela A.
Alonso, María Rosario
Anesini, Claudia
author_facet Martino, Renzo
Barreiro Arcos, María Laura
Peralta, Ignacio
Marrassini, Carla
Saint Martin, Elina Malén
Cogoi, Laura
Cremaschi, Graciela A.
Alonso, María Rosario
Anesini, Claudia
author_sort Martino, Renzo
title Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
title_short Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
title_full Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
title_fullStr Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
title_full_unstemmed Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
title_sort antiproliferative activity of aqueous and polyphenol-rich extracts of larrea divaricata cav. upon a melanoma cell line
publisher Taylor and Francis
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12861
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