Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing

Abstract: The pressing call to detect sensitive cognitive markers of frontal lobe epilepsy (FLE) remains poorly addressed. Standard frameworks prove nosologically unspecific (as they reveal deficits that also emerge across other epilepsy subtypes), possess low ecological validity, and are rarely su...

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Detalles Bibliográficos
Autores principales: Moguilner, Sebastian, Birba, Agustina, Fino, Daniel, Isoardi, Roberto, Huetagoyena, Celeste, Otoya, Raúl, Tirapu, Viviana, Cremaschi, Fabián, Sedeño, Lucas, Ibáñez, Agustín, García, Adolfo M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2021
Materias:
EPILEPSIA DEL LOBULO FRONTAL
APRENDIZAJE AUTOMATICO
MARCADORES COGNITIVOS
NEUROIMAGEN MULTIMODAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12705
https://doi.org/10.1016/j.neuroimage.2021.117998
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-12705
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic EPILEPSIA DEL LOBULO FRONTAL
APRENDIZAJE AUTOMATICO
MARCADORES COGNITIVOS
NEUROIMAGEN MULTIMODAL
spellingShingle EPILEPSIA DEL LOBULO FRONTAL
APRENDIZAJE AUTOMATICO
MARCADORES COGNITIVOS
NEUROIMAGEN MULTIMODAL
Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Isoardi, Roberto
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
topic_facet EPILEPSIA DEL LOBULO FRONTAL
APRENDIZAJE AUTOMATICO
MARCADORES COGNITIVOS
NEUROIMAGEN MULTIMODAL
description Abstract: The pressing call to detect sensitive cognitive markers of frontal lobe epilepsy (FLE) remains poorly addressed. Standard frameworks prove nosologically unspecific (as they reveal deficits that also emerge across other epilepsy subtypes), possess low ecological validity, and are rarely supported by multimodal neuroimaging assessments. To bridge these gaps, we examined naturalistic action and non-action text comprehension, combined with structural and functional connectivity measures, in 19 FLE patients, 19 healthy controls, and 20 posterior cortex epilepsy (PCE) patients. Our analyses integrated inferential statistics and data-driven machine-learning classifiers. FLE patients were selectively and specifically impaired in action comprehension, irrespective of their neuropsychological profile. These deficits selectively and specifically correlated with (a) reduced integrity of the anterior thalamic radiation, a subcortical structure underlying motoric and action-language processing as well as epileptic seizure spread in this subtype; and (b) hypoconnectivity between the primary motor cortex and the left-parietal/supramarginal regions, two putative substrates of action-language comprehension. Moreover, machine-learning classifiers based on the above neurocognitive measures yielded 75% accuracy rates in discriminating individual FLE patients from both controls and PCE patients. Briefly, action-text assessments, combined with structural and functional connectivity measures, seem to capture ecological cognitive deficits that are specific to FLE, opening new avenues for discriminatory characterizations among epilepsy types.
format Artículo
author Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Isoardi, Roberto
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
author_facet Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Isoardi, Roberto
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
author_sort Moguilner, Sebastian
title Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
title_short Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
title_full Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
title_fullStr Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
title_full_unstemmed Multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
title_sort multimodal neurocognitive markers of frontal lobe epilepsy: insights from ecological text processing
publisher Elsevier
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12705
https://doi.org/10.1016/j.neuroimage.2021.117998
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