The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene

Abstract: Parkinson’s disease (PD) is an extrapyramidal disorder characterized by neuronal degeneration in several regions of the peripheral and central nervous systems. It is the second most frequent neurodegenerative disease after Alzheimer’s. It has become a major health problem, affecting 1%...

Descripción completa

Detalles Bibliográficos
Autores principales: Kobiec, Tamara, Otero Losada, Matilde, Chevalier, Guenson, Udovin, Lucas Daniel, Bordet, Sofía, Menéndez Maissonave, Camila Belén, Capani, Francisco, Pérez Lloret, Santiago
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2021
Materias:
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEURODEGENERATIVAS
SINAPSIS
NEUROTRANSMISORES
NEURODEGENERACION
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11462
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-11462
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE PARKINSON
ENFERMEDADES NEURODEGENERATIVAS
SINAPSIS
NEUROTRANSMISORES
NEURODEGENERACION
spellingShingle ENFERMEDAD DE PARKINSON
ENFERMEDADES NEURODEGENERATIVAS
SINAPSIS
NEUROTRANSMISORES
NEURODEGENERACION
Kobiec, Tamara
Otero Losada, Matilde
Chevalier, Guenson
Udovin, Lucas Daniel
Bordet, Sofía
Menéndez Maissonave, Camila Belén
Capani, Francisco
Pérez Lloret, Santiago
The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
topic_facet ENFERMEDAD DE PARKINSON
ENFERMEDADES NEURODEGENERATIVAS
SINAPSIS
NEUROTRANSMISORES
NEURODEGENERACION
description Abstract: Parkinson’s disease (PD) is an extrapyramidal disorder characterized by neuronal degeneration in several regions of the peripheral and central nervous systems. It is the second most frequent neurodegenerative disease after Alzheimer’s. It has become a major health problem, affecting 1% of the world population over 60 years old and 3% of people beyond 80 years. The main histological findings are intracellular Lewy bodies composed of misfolded a-synuclein protein aggregates and loss of dopaminergic neurons in the central nervous system. Neuroinflammation, apoptosis, mitochondrial dysfunction, altered calcium homeostasis, abnormal protein degradation, and synaptic pathobiology have been put forward as mechanisms leading to cell death, a-synuclein deposition, or both. A progressive loss of dopaminergic neurons in the substantia nigra late in the neurodegeneration leads to developing motor symptoms like bradykinesia, tremor, and rigidity. The renin–angiotensin system (RAS), which is involved in regulating blood pressure and body fluid balance, also plays other important functions in the brain. The RAS is involved in the autocrine and paracrine regulation of the nigrostriatal dopaminergic synapses. Dopamine depletion, as in PD, increases angiotensin II expression, which stimulates or inhibits dopamine synthesis and is released via AT1 or AT2 receptors.
format Artículo
author Kobiec, Tamara
Otero Losada, Matilde
Chevalier, Guenson
Udovin, Lucas Daniel
Bordet, Sofía
Menéndez Maissonave, Camila Belén
Capani, Francisco
Pérez Lloret, Santiago
author_facet Kobiec, Tamara
Otero Losada, Matilde
Chevalier, Guenson
Udovin, Lucas Daniel
Bordet, Sofía
Menéndez Maissonave, Camila Belén
Capani, Francisco
Pérez Lloret, Santiago
author_sort Kobiec, Tamara
title The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
title_short The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
title_full The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
title_fullStr The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
title_full_unstemmed The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
title_sort renin–angiotensin system modulates dopaminergic neurotransmission : a new player on the scene
publisher Frontiers
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/11462
work_keys_str_mv AT kobiectamara thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT oterolosadamatilde thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT chevalierguenson thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT udovinlucasdaniel thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT bordetsofia thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT menendezmaissonavecamilabelen thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT capanifrancisco thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT perezlloretsantiago thereninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT kobiectamara reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT oterolosadamatilde reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT chevalierguenson reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT udovinlucasdaniel reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT bordetsofia reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT menendezmaissonavecamilabelen reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT capanifrancisco reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
AT perezlloretsantiago reninangiotensinsystemmodulatesdopaminergicneurotransmissionanewplayeronthescene
bdutipo_str Repositorios
_version_ 1764820524766068737

Ejemplares similares