Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort

Abstract: Introduction: We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this...

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Autores principales: Rascol, Olivier, Negre-Pages, Laurence, Damier, Philippe, Delval, Arnaud, Derkinderen, Pascal, Destée, Alain, Fabbri, Margherita, Meissner, Wassilios G., Rachdi, Amine, Tison, François, Pérez Lloret, Santiago
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
ENFERMEDAD DE PARKINSON
GLANDULAS SALIVALES
SISTEMA NERVIOSO AUTONOMO
CALIDAD DE VIDA
TRATAMIENTO MEDICO
ENFERMEDADES NEUROGENERATIVAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10859
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10859
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE PARKINSON
GLANDULAS SALIVALES
SISTEMA NERVIOSO AUTONOMO
CALIDAD DE VIDA
TRATAMIENTO MEDICO
ENFERMEDADES NEUROGENERATIVAS
spellingShingle ENFERMEDAD DE PARKINSON
GLANDULAS SALIVALES
SISTEMA NERVIOSO AUTONOMO
CALIDAD DE VIDA
TRATAMIENTO MEDICO
ENFERMEDADES NEUROGENERATIVAS
Rascol, Olivier
Negre-Pages, Laurence
Damier, Philippe
Delval, Arnaud
Derkinderen, Pascal
Destée, Alain
Fabbri, Margherita
Meissner, Wassilios G.
Rachdi, Amine
Tison, François
Pérez Lloret, Santiago
Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
topic_facet ENFERMEDAD DE PARKINSON
GLANDULAS SALIVALES
SISTEMA NERVIOSO AUTONOMO
CALIDAD DE VIDA
TRATAMIENTO MEDICO
ENFERMEDADES NEUROGENERATIVAS
description Abstract: Introduction: We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition. Methods: We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined “sialorrhea” as UPDRS item #6 (salivation)=1 or 2; and “drooling” as item #6=3 or 4. SCOPA-Aut drooling score (item #2) was also available in a subset (45%) of the cohort. HRQoL was assessed by the PDQ-39 and SF-36 scales. Twenty-four months follow-up data was available in 401/671 patients. Results: EBS as assessed by UPDRS was present in 38% of PD patients in the “ON” condition (“Sialorrhea”: 35%; “drooling”: 3%). There were also more PD patients reporting “drooling” than controls according to the SCOPA-Aut (49% vs 19%, p<0.01). UPDRS salivation score was worse in the “OFF” vs “ON” condition in PD patients with motor fluctuations (0.90±0.94 vs 0.54±0.79, p<0.01). UPDRS salivation score worsened after 24 months of follow up (0.47±0.70 vs 0.64±0.81, p<0.01). Worse PDQ-39 scores were observed in PD patients with EBS in bivariate but not in multivariate analyses. EBS was directly related to PD duration and severity, male gender, dysphagia, hypomimia, and autonomic dysfunction (logistic regression). Conclusions: EBS was more frequent in PD patients than controls, worsened in the “OFF” condition and after 24 months of follow-up, moderately affected HRQoL and was correlated with indices of bradykinesia, dysphagia, and autonomic dysfunction.
format Artículo
author Rascol, Olivier
Negre-Pages, Laurence
Damier, Philippe
Delval, Arnaud
Derkinderen, Pascal
Destée, Alain
Fabbri, Margherita
Meissner, Wassilios G.
Rachdi, Amine
Tison, François
Pérez Lloret, Santiago
author_facet Rascol, Olivier
Negre-Pages, Laurence
Damier, Philippe
Delval, Arnaud
Derkinderen, Pascal
Destée, Alain
Fabbri, Margherita
Meissner, Wassilios G.
Rachdi, Amine
Tison, François
Pérez Lloret, Santiago
author_sort Rascol, Olivier
title Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
title_short Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
title_full Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
title_fullStr Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
title_full_unstemmed Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
title_sort excessive buccal saliva in patients with parkinson’s disease of the french copark cohort
publisher Springer Nature
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10859
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