Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses

Abstract: As the coronavirus disease 2019 (COVID-19) pandemic unfolds, neurological signs and symptoms reflect the involvement of targets beyond the primary lung affectation. The etiological agent of COVID-19, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits neurotropism...

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Detalles Bibliográficos
Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: American Chemical Society 2020
Materias:
MEDICINA
COVID-19
SARS-CoV-2
PANDEMIA
INFECCIONES
VIRUS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10846
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10846
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
COVID-19
SARS-CoV-2
PANDEMIA
INFECCIONES
VIRUS
spellingShingle MEDICINA
COVID-19
SARS-CoV-2
PANDEMIA
INFECCIONES
VIRUS
Barrantes, Francisco José
Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
topic_facet MEDICINA
COVID-19
SARS-CoV-2
PANDEMIA
INFECCIONES
VIRUS
description Abstract: As the coronavirus disease 2019 (COVID-19) pandemic unfolds, neurological signs and symptoms reflect the involvement of targets beyond the primary lung affectation. The etiological agent of COVID-19, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits neurotropism for central and peripheral nervous systems. Various infective mechanisms and paths can be exploited by the virus to reach the central nervous system, some of which bypass the blood-brain-barrier; others alter its integrity. Numerous studies have established beyond doubt that the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) performs the role of SARS-CoV-2 host-cell receptor. Histochemical studies and more recently transcriptomics of mRNA have dissected the cellular localization of the ACE2 enzyme in various tissues, including the central nervous system. Epithelial cells lining the nasal mucosae, the upper respiratory tract and the oral cavity, bronchoalveolar cells type II in the pulmonary parenchyma and intestinal enterocytes display ACE2 binding sites at their cell surfaces, making these epithelial mucosae the most likely viral entry points. Neuronal and glial cells and endothelial cells in the central nervous system also express ACE2. This short review analyzes the known entry points and routes followed by the SARS-CoV-2 to reach the central nervous system, and postulates new hypothetical pathways stemming from the enterocytes lining the intestinal lumen.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
title_short Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
title_full Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
title_fullStr Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
title_full_unstemmed Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
title_sort central nervous system targets and routes for sars-cov-2 : current views and new hypotheses
publisher American Chemical Society
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10846
work_keys_str_mv AT barrantesfranciscojose centralnervoussystemtargetsandroutesforsarscov2currentviewsandnewhypotheses
bdutipo_str Repositorios
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