White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease
Abstract: Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer’s disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with disease prevention efforts. The microstructure of these tracts and ana...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/10116 |
| Aporte de: |
| id |
I33-R139123456789-10116 |
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| record_format |
dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS PREVENCION Y CONTROL DIAGNOSTICO TRATAMIENTO MEDICO RESONANCIA MAGNETICA NUCLEAR FUNCION COGNITIVA EVALUACION NEUROPSICOLOGICA |
| spellingShingle |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS PREVENCION Y CONTROL DIAGNOSTICO TRATAMIENTO MEDICO RESONANCIA MAGNETICA NUCLEAR FUNCION COGNITIVA EVALUACION NEUROPSICOLOGICA Sánchez, Stella M. Duarte-Abritta, Bárbara Abulafia, Carolina Andrea De Pino, Gabriela Bocaccio, Hernan Castro, Mariana N. Sevlever, Gustavo Fonzo, Greg A. Nemeroff, Charles B. Gustafson, Deborah R. Guinjoan, Salvador M. Villarreal, Mirta F. White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| topic_facet |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS PREVENCION Y CONTROL DIAGNOSTICO TRATAMIENTO MEDICO RESONANCIA MAGNETICA NUCLEAR FUNCION COGNITIVA EVALUACION NEUROPSICOLOGICA |
| description |
Abstract: Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset
Alzheimer’s disease (LOAD). There is a need to ascertain methods for the detection of early LOAD
features to help with disease prevention efforts. The microstructure of these tracts and anatomical
brain connectivity can be assessed by analyzing diffusion MRI (dMRI) data. Considering that family
history increases the risk of developing LOAD, we explored the microstructure of white matter
through dMRI in 23 cognitively normal adults who are offspring of patients with Late-Onset
Alzheimer’s Disease (O-LOAD) and 22 control subjects (CS) without family history of AD. We also
evaluated the relation of white matter microstructure metrics with cortical thickness, volumetry, in
vivo amyloid deposition (with the help of PiB positron emission tomography -PiB-PET) and regional
brain metabolism (as FDG-PET) measures. Finally we studied the association between cognitive
performance and white matter microstructure metrics. O-LOAD exhibited lower fiber density and
fractional anisotropy in the posterior portion of the corpus callosum and right fornix when compared
to CS. Among O-LOAD, reduced fiber density was associated with lower amyloid deposition in the
right hippocampus, and greater cortical thickness in the left precuneus, while higher mean
diffusivity was related with greater cortical thickness of the right superior temporal gyrus.
Additionally, compromised white matter microstructure was associated with poorer semantic
fluency. In conclusion, white matter microstructure metrics may reveal early differences in O-LOAD
by virtue of parental history of the disorder, when compared to CS without a family history of
LOAD. We demonstrate that these differences are associated with lower fiber density in the
posterior portion of the corpus callosum and the right fornix. |
| format |
Artículo |
| author |
Sánchez, Stella M. Duarte-Abritta, Bárbara Abulafia, Carolina Andrea De Pino, Gabriela Bocaccio, Hernan Castro, Mariana N. Sevlever, Gustavo Fonzo, Greg A. Nemeroff, Charles B. Gustafson, Deborah R. Guinjoan, Salvador M. Villarreal, Mirta F. |
| author_facet |
Sánchez, Stella M. Duarte-Abritta, Bárbara Abulafia, Carolina Andrea De Pino, Gabriela Bocaccio, Hernan Castro, Mariana N. Sevlever, Gustavo Fonzo, Greg A. Nemeroff, Charles B. Gustafson, Deborah R. Guinjoan, Salvador M. Villarreal, Mirta F. |
| author_sort |
Sánchez, Stella M. |
| title |
White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| title_short |
White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| title_full |
White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| title_fullStr |
White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| title_full_unstemmed |
White matter fiber density abnormalities in cognitively normal adults at risk for lateonset Alzheimer´s disease |
| title_sort |
white matter fiber density abnormalities in cognitively normal adults at risk for lateonset alzheimer´s disease |
| publisher |
Elsevier |
| publishDate |
2020 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/10116 |
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