Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway

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Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correl...

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Autores principales: Cheng, Yan, Xing-Hua, Gao, Li, Xian-Jing, Cao, Qiuhua, Zhao, Dan-Dan, Zhou, Jin-Rong, Wu, Hong-Xi, Wang, Yun, You, Lin-Jun, Yang, Hong-Bao, He, Yun Long, Li, Yong-Ren, Bian, Jin-Song, Zhu, Qing-Yi, Birnbaumer, Lutz, Yang, Yong
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
CANCER
DEPRESION
METASTASIS
TRATAMIENTO MEDICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9360
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-9360
record_format dspace
spelling I33-R139-123456789-93602024-03-26T10:46:54Z Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway Cheng, Yan Xing-Hua, Gao Li, Xian-Jing Cao, Qiuhua Zhao, Dan-Dan Zhou, Jin-Rong Wu, Hong-Xi Wang, Yun You, Lin-Jun Yang, Hong-Bao He, Yun Long Li, Yong-Ren Bian, Jin-Song Zhu, Qing-Yi Birnbaumer, Lutz Yang, Yong CANCER DEPRESION METASTASIS TRATAMIENTO MEDICO Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation of a sympathetic-FAK signaling pathway in prostate cancer patients with high degrees of depression facilitates tumor invasion. We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer. 2020-02-11T22:43:34Z 2020-02-11T22:43:34Z 2018 Artículo Cheng, Y., Xing-Hua, G., Li, Xian-J., et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway [en línea]. Oncogene. 2018, 37. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9360 0950-9232 (impreso) 1476-5594 (en línea) https://repositorio.uca.edu.ar/handle/123456789/9360 10.1038/s41388-018-0177-4 29515233 eng Acceso Abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Nature Oncogene. 2018, 37
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER
DEPRESION
METASTASIS
TRATAMIENTO MEDICO
spellingShingle CANCER
DEPRESION
METASTASIS
TRATAMIENTO MEDICO
Cheng, Yan
Xing-Hua, Gao
Li, Xian-Jing
Cao, Qiuhua
Zhao, Dan-Dan
Zhou, Jin-Rong
Wu, Hong-Xi
Wang, Yun
You, Lin-Jun
Yang, Hong-Bao
He, Yun Long
Li, Yong-Ren
Bian, Jin-Song
Zhu, Qing-Yi
Birnbaumer, Lutz
Yang, Yong
Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
topic_facet CANCER
DEPRESION
METASTASIS
TRATAMIENTO MEDICO
description Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation of a sympathetic-FAK signaling pathway in prostate cancer patients with high degrees of depression facilitates tumor invasion. We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer.
format Artículo
author Cheng, Yan
Xing-Hua, Gao
Li, Xian-Jing
Cao, Qiuhua
Zhao, Dan-Dan
Zhou, Jin-Rong
Wu, Hong-Xi
Wang, Yun
You, Lin-Jun
Yang, Hong-Bao
He, Yun Long
Li, Yong-Ren
Bian, Jin-Song
Zhu, Qing-Yi
Birnbaumer, Lutz
Yang, Yong
author_facet Cheng, Yan
Xing-Hua, Gao
Li, Xian-Jing
Cao, Qiuhua
Zhao, Dan-Dan
Zhou, Jin-Rong
Wu, Hong-Xi
Wang, Yun
You, Lin-Jun
Yang, Hong-Bao
He, Yun Long
Li, Yong-Ren
Bian, Jin-Song
Zhu, Qing-Yi
Birnbaumer, Lutz
Yang, Yong
author_sort Cheng, Yan
title Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
title_short Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
title_full Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
title_fullStr Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
title_full_unstemmed Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
title_sort depression promotes prostate cancer invasion and metastasis via a sympathetic-camp-fak signaling pathway
publisher Springer Nature
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9360
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