Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective

Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences o...

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Autores principales: Kobiec, Tamara, Mardaraz, Claudia, Toro Urrego, Nicolás, Kölliker Frers, Rodolfo, Capani, Francisco, Otero Losada, Matilde
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2023
Materias:
SINDROME METABOLICO
NEUROPROTECCION
NEURODESARROLLO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/17275
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Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-17275
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spelling I33-R139-123456789-172752024-02-08T19:12:02Z Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective Kobiec, Tamara Mardaraz, Claudia Toro Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco Otero Losada, Matilde SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan. 2023-10-12T10:44:51Z 2023-10-12T10:44:51Z 2023 Artículo Kobiec, T. Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective [en línea]. Frontiers in Neuroscience. 2023, 17: 1214468. doi: 10.3389/fnins.2023.1214468 . Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17275 1662-453X (online) https://repositorio.uca.edu.ar/handle/123456789/17275 10.3389/fnins.2023.1214468 eng Neuroprotección en asfixia perinatal desde un enfoque traslacional Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Frontiers in Neuroscience. Vol.17: 1214468, 2023
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic SINDROME METABOLICO
NEUROPROTECCION
NEURODESARROLLO
spellingShingle SINDROME METABOLICO
NEUROPROTECCION
NEURODESARROLLO
Kobiec, Tamara
Mardaraz, Claudia
Toro Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
Otero Losada, Matilde
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
topic_facet SINDROME METABOLICO
NEUROPROTECCION
NEURODESARROLLO
description Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan.
format Artículo
author Kobiec, Tamara
Mardaraz, Claudia
Toro Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
Otero Losada, Matilde
author_facet Kobiec, Tamara
Mardaraz, Claudia
Toro Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
Otero Losada, Matilde
author_sort Kobiec, Tamara
title Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
title_short Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
title_full Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
title_fullStr Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
title_full_unstemmed Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
title_sort neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
publisher Frontiers Media
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/17275
work_keys_str_mv AT kobiectamara neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
AT mardarazclaudia neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
AT torourregonicolas neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
AT kollikerfrersrodolfo neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
AT capanifrancisco neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
AT oterolosadamatilde neuroprotectioninmetabolicsyndromebyenvironmentalenrichmentalifespanperspective
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