Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging

Abstract: Background: Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and metastatic cancer. It is not easy to clinically evaluate the chemotoxic or...

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Autores principales: Tesan, Fiorella Carla, Portillo, Mariano Gaston, Martinel Lamas, Diego José, Medina, Vanina Araceli, Salgueiro, Maria Jimena, Zubillaga, Marcela Beatriz
Formato: Artículo
Lenguaje:Inglés
Publicado: Bentham Science 2022
Materias:
HISTAMINA
ESTRUCTURA MOLECULAR
DOXORRUBICINA
HIGADO
CORAZON
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15249
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15249
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic HISTAMINA
ESTRUCTURA MOLECULAR
DOXORRUBICINA
HIGADO
CORAZON
spellingShingle HISTAMINA
ESTRUCTURA MOLECULAR
DOXORRUBICINA
HIGADO
CORAZON
Tesan, Fiorella Carla
Portillo, Mariano Gaston
Martinel Lamas, Diego José
Medina, Vanina Araceli
Salgueiro, Maria Jimena
Zubillaga, Marcela Beatriz
Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
topic_facet HISTAMINA
ESTRUCTURA MOLECULAR
DOXORRUBICINA
HIGADO
CORAZON
description Abstract: Background: Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and metastatic cancer. It is not easy to clinically evaluate the chemotoxic or chemoprotective effect of some drugs, even more when there is a subclinical toxicity. Objective: To determine the usefulness of the hepatobiliary, colloid and cardiac scintigraphies, employing 99mTcdisida, 99mTc-phytate and 99mTc-sestamibi respectively, in the evaluation of the hepato and cardiotoxicity of two chemotherapeutic treatments assessed in rats. Method: Two groups were submitted to doxorubicin (DOX) treatment and one was co-administered with histamine (DOX+HIS). Static 99mTc-phytate and 99mTc-sestamibi scintigraphies as well as a dynamic 99mTc-disida study were performed in a small field of view gamma camera at: 0 weeks (control), 1 week and 2 weeks of treatment. Imagenological parameters were calculated: Liver/Bone Marrow ratio (L/BM), Heart/Background ratio (H/B) and time to the maximum (Tmax) for 99mTc-phytate, 99mTc-sestamibi and 99mTc-disida extraction, respectively. Results: Control (L/BM= 98±3; H/B=2.3±0.4; Tmax=8±3), DOX (L/BM: 85±3, 80±3; H/B, 3.5±0.5, 3.3±0.5 and Tmax 6±1, 4±1) for 1 and 2 weeks respectively and DOX+HIS (L/BM: 99±0.3, 98±1; H/B 2.9±0.5, 2.9±0.5 and Tmax, 8±2, 9±2) for 1 and 2 weeks, respectively. Histological analysis showed cardio and hepatotoxicity induced by doxorubicin. Conclusion: Imagenological parameters showed differences among treated and control groups and between both chemotherapy treatments. Thus, these radiopharmaceutical functional approaches were able to reflect heart and liver toxicity produced by doxorubicin.
format Artículo
author Tesan, Fiorella Carla
Portillo, Mariano Gaston
Martinel Lamas, Diego José
Medina, Vanina Araceli
Salgueiro, Maria Jimena
Zubillaga, Marcela Beatriz
author_facet Tesan, Fiorella Carla
Portillo, Mariano Gaston
Martinel Lamas, Diego José
Medina, Vanina Araceli
Salgueiro, Maria Jimena
Zubillaga, Marcela Beatriz
author_sort Tesan, Fiorella Carla
title Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
title_short Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
title_full Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
title_fullStr Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
title_full_unstemmed Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
title_sort hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging
publisher Bentham Science
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15249
work_keys_str_mv AT tesanfiorellacarla hepatoandcardiotoxicityofchemotherapeutictreatmentevaluatedbymeansofsmallanimalimaging
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bdutipo_str Repositorios
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