Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver

Abstract: Benzo(a)pyrene (BaP), an important environmental pollutant, is produced as the result of incomplete combustion of organic materials in many industries and food cooking process. It has been purposed that BaP induces hepatotoxicity through oxidative stress and apoptosis. Several studies have...

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Autores principales: Barangi, Samira, Mehri, Soghra, Moosavi, Zahra, Hayesd, A Wallace, Reiter, Russel J., Cardinali, Daniel Pedro, Karimi, Gholamreza
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
APOPTOSIS
ANTIOXIDANTES
RIÑON
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15210
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15210
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic APOPTOSIS
ANTIOXIDANTES
RIÑON
MELATONINA
spellingShingle APOPTOSIS
ANTIOXIDANTES
RIÑON
MELATONINA
Barangi, Samira
Mehri, Soghra
Moosavi, Zahra
Hayesd, A Wallace
Reiter, Russel J.
Cardinali, Daniel Pedro
Karimi, Gholamreza
Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
topic_facet APOPTOSIS
ANTIOXIDANTES
RIÑON
MELATONINA
description Abstract: Benzo(a)pyrene (BaP), an important environmental pollutant, is produced as the result of incomplete combustion of organic materials in many industries and food cooking process. It has been purposed that BaP induces hepatotoxicity through oxidative stress and apoptosis. Several studies have shown that melatonin can protect against chemical-induced apoptosis through autophagy pathway. In this study, we assessed the modulating effect of melatonin, a well-known antioxidant, on BaP-induced hepatotoxicity through induction of autophagy. Thirty male mice were treated daily for 28 consecutive days. BaP (75 mg/kg; oral gavage) and melatonin (10 and 20 mg/kg, i.p.) were administered to mice. The liver histopathology and the levels of apoptosis and autophagy proteins as well as the expression of miR-34a were determined. The BaP exposure induced severe liver histological injury and markedly enhanced AST, ALT and MDA level. Also, apoptosis proteins and hepatic miR-34a expression increased. However, the level of Sirt1 and autophagy markers such as LC3 II/I ratio and Beclin-1 reduced. The co-administration of melatonin reversed all changes caused by BaP. In summary, melatonin appears to be effective in BaP-induced hepatotoxicity maybe through the miR-34a/Sirt1/autophagy molecular pathway.
format Artículo
author Barangi, Samira
Mehri, Soghra
Moosavi, Zahra
Hayesd, A Wallace
Reiter, Russel J.
Cardinali, Daniel Pedro
Karimi, Gholamreza
author_facet Barangi, Samira
Mehri, Soghra
Moosavi, Zahra
Hayesd, A Wallace
Reiter, Russel J.
Cardinali, Daniel Pedro
Karimi, Gholamreza
author_sort Barangi, Samira
title Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
title_short Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
title_full Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
title_fullStr Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
title_full_unstemmed Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver
title_sort melatonin inhibits benzo(a)pyrene-induced apoptosis through activation of the mir-34a/sirt1/autophagy pathway in mouse liver
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15210
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