Nicotine modulates mitochondrial dynamics in hippocampal neurons

Abstract: Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerge...

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Detalles Bibliográficos
Autores principales: Godoy, Juan A., Valdivieso, Ángel Gabriel, Inestrosa, Nibaldo C.
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2022
Materias:
MITOCONDRIAS
NICOTINA
NEURONAS
HIPOCAMPO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14725
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14725
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MITOCONDRIAS
NICOTINA
NEURONAS
HIPOCAMPO
spellingShingle MITOCONDRIAS
NICOTINA
NEURONAS
HIPOCAMPO
Godoy, Juan A.
Valdivieso, Ángel Gabriel
Inestrosa, Nibaldo C.
Nicotine modulates mitochondrial dynamics in hippocampal neurons
topic_facet MITOCONDRIAS
NICOTINA
NEURONAS
HIPOCAMPO
description Abstract: Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable of determining cellular fate. Mitochondria-related functions have proven particularly relevant in neurons; mitochondria are necessary for proper neuronal morphogenesis and the highly energy-demanding synaptic transmission process. Mitochondrial health depends on balanced fusion-fission events, termed mitochondrial dynamics, to repair damaged organelles and/or improve the quality of mitochondrial function, ATP production, calcium homeostasis, and apoptosis, which represent some mitochondrial functions closely related to mitochondrial dynamics. Several neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases, have been correlated with severe mitochondrial dysfunction. In this regard, nicotine, which has been associated with relevant neuroprotective effects mainly through activation of the nicotinic acetylcholine receptor (nAChR), exerts its effects at least in part by acting directly on mitochondrial physiology and morphology. Additionally, a recent description of mitochondrial nAChR localization suggests a nicotine-dependent mitochondrial function. In the present work, we evaluated in cultured hipocampal neurons the effects of nicotine on mitochondrial dynamics by assessing mitochondrial morphology, membrane potential, as well as interactions between mitochondria, cytoskeleton and IP3R, levels of the cofactor PGC-1α, and fission-fusion-related proteins. Our results suggest that nicotine modulates mitochondrial dynamics and influences mitochondrial association from microtubules, increasing IP3 receptor clustering showing modulation between mitochondria-ER communications, together with the increase of mitochondrial biogenesis.
format Artículo
author Godoy, Juan A.
Valdivieso, Ángel Gabriel
Inestrosa, Nibaldo C.
author_facet Godoy, Juan A.
Valdivieso, Ángel Gabriel
Inestrosa, Nibaldo C.
author_sort Godoy, Juan A.
title Nicotine modulates mitochondrial dynamics in hippocampal neurons
title_short Nicotine modulates mitochondrial dynamics in hippocampal neurons
title_full Nicotine modulates mitochondrial dynamics in hippocampal neurons
title_fullStr Nicotine modulates mitochondrial dynamics in hippocampal neurons
title_full_unstemmed Nicotine modulates mitochondrial dynamics in hippocampal neurons
title_sort nicotine modulates mitochondrial dynamics in hippocampal neurons
publisher Springer
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14725
work_keys_str_mv AT godoyjuana nicotinemodulatesmitochondrialdynamicsinhippocampalneurons
AT valdiviesoangelgabriel nicotinemodulatesmitochondrialdynamicsinhippocampalneurons
AT inestrosanibaldoc nicotinemodulatesmitochondrialdynamicsinhippocampalneurons
bdutipo_str Repositorios
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