Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration

Abstract: Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills all these functions plus those inherent to the specific functio...

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Detalles Bibliográficos
Autores principales: Quintá, Héctor R., Barrantes, Francisco José
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Elservier 2022
Materias:
AXONES
MEMBRANAS CELULARES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14690
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14690
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic AXONES
MEMBRANAS CELULARES
spellingShingle AXONES
MEMBRANAS CELULARES
Quintá, Héctor R.
Barrantes, Francisco José
Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
topic_facet AXONES
MEMBRANAS CELULARES
description Abstract: Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills all these functions plus those inherent to the specific function of the neuron: maintaining the membrane potential by the regulated and concerted operation of ion-selective channels. Membrane expansion and neurite growth are directly linked through intricate cellular signaling mechanisms during the early stages of embryonic development. During axonal development there is an increase in the surface area of the axolemma which provokes an increase in membrane tension. Membrane insertion involved in axonal growth reduces the membrane tension, and this in turn allows distal membrane expansion and axonal extension. Under certain pathological conditions, such as spinal cord and traumatic brain injuries, the axolemmal damage results in different degrees of neuronal degeneration due to unregulated ionic influx, followed by oxidative damage, finally triggering neuronal apoptosis. Neurons possess counteractive mechanisms to arrest these degenerative processes which involve sealing the axolemma as a first step toward membrane repair, followed by attempts at axonal extension. In this review we address the main molecular actors and mechanisms involved in axonal growth during embryonic development and the recapitulation of these mechanisms during the posttraumatic regeneration process. We also discuss the efficacy of some classical and novel therapeutic approaches to axolemmal sealing and repair in different pathologies.
format Parte de libro
author Quintá, Héctor R.
Barrantes, Francisco José
author_facet Quintá, Héctor R.
Barrantes, Francisco José
author_sort Quintá, Héctor R.
title Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_short Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_full Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_fullStr Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_full_unstemmed Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
title_sort damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration
publisher Elservier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14690
work_keys_str_mv AT quintahectorr damageandrepairoftheaxolemmalmembranefromneuraldevelopmenttoaxonaltraumaandrestoration
AT barrantesfranciscojose damageandrepairoftheaxolemmalmembranefromneuraldevelopmenttoaxonaltraumaandrestoration
bdutipo_str Repositorios
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