Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease

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Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism...

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Autores principales: Abulafia, Carolina Andrea, Duarte-Abritta, Bárbara, Villareal, Mirta F., García, Celeste, Sequeyra, Geraldine, Sevlever, Gustavo, Fiorentini, Leticia, Bär, Karl-Jürgen, Gustafson, Deborah R., Vigo, Daniel Eduardo, Guinjoan, Salvador M., Ladrón de Guevara, María Soledad
Formato: Artículo
Lenguaje:Español
Inglés
Publicado: Frontiers Media 2019
Materias:
ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1463
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-1463
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spelling I33-R139-123456789-14632024-03-26T11:31:18Z Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease Abulafia, Carolina Andrea Duarte-Abritta, Bárbara Villareal, Mirta F. García, Celeste Sequeyra, Geraldine Sevlever, Gustavo Fiorentini, Leticia Bär, Karl-Jürgen Gustafson, Deborah R. Vigo, Daniel Eduardo Guinjoan, Salvador M. Ladrón de Guevara, María Soledad ENFERMEDAD DE ALZHEIMER PROCESO COGNITIVO SUEÑO RITMO CIRCADIANO Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals. 2019-05-02T13:56:20Z 2019-05-02T13:56:20Z 2017 Artículo Abulafia, C., et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience. 2017, 9. doi:10.3389/fnagi.2017.00093. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1463 1663-4365 (online) https://repositorio.uca.edu.ar/handle/123456789/1463 10.3389/fnagi.2017.00093 spa eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Frontiers in Aging Neuroscience, Vol. 9, 2017
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
Inglés
topic ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
spellingShingle ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
topic_facet ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
description Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
format Artículo
author Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
author_facet Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Ladrón de Guevara, María Soledad
author_sort Abulafia, Carolina Andrea
title Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_short Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_fullStr Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full_unstemmed Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_sort relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
publisher Frontiers Media
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1463
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