Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration

Abstract: Non-exudative age-related macular degeneration (NE-AMD), the main cause of blindness in people above 50 years old, lacks effective treatments at the moment. We have developed a new NE-AMD model through unilateral superior cervical ganglionectomy (SCGx), which elicits the disease main feat...

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Autores principales:	Dieguez, Hernán H., Calanni, Juan S., Romeo, Horacio, Alaimo, Agustina, González Fleitas, María F., Iaquinandi, Agustina, Chianelli, Mónica S., Keller Sarmiento, María I., Sande, Pablo H., Rosenstein, Ruth E., Dorfman, Damián
Formato:	Artículo
Lenguaje:	Inglés
Publicado:	Nature Research 2022
Materias:	DEGENERACIÓN MACULAR FISIOPATOLOGÍA CÉLULAS FOTORRECEPTORAS EPITELIO PIGMENTARIO DE LA RETINA OFTALMOLOGIA FACTORES DE EDAD CEGUERA ADULTOS
Acceso en línea:	https://repositorio.uca.edu.ar/handle/123456789/14600
Aporte de:	Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina

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institution	Universidad Católica Argentina
institution_str	I-33
repository_str	R-139
collection	Repositorio Institucional de la Universidad Católica Argentina (UCA)
language	Inglés
topic	DEGENERACIÓN MACULAR FISIOPATOLOGÍA CÉLULAS FOTORRECEPTORAS EPITELIO PIGMENTARIO DE LA RETINA OFTALMOLOGIA FACTORES DE EDAD CEGUERA ADULTOS
spellingShingle	DEGENERACIÓN MACULAR FISIOPATOLOGÍA CÉLULAS FOTORRECEPTORAS EPITELIO PIGMENTARIO DE LA RETINA OFTALMOLOGIA FACTORES DE EDAD CEGUERA ADULTOS Dieguez, Hernán H. Calanni, Juan S. Romeo, Horacio Alaimo, Agustina González Fleitas, María F. Iaquinandi, Agustina Chianelli, Mónica S. Keller Sarmiento, María I. Sande, Pablo H. Rosenstein, Ruth E. Dorfman, Damián Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
topic_facet	DEGENERACIÓN MACULAR FISIOPATOLOGÍA CÉLULAS FOTORRECEPTORAS EPITELIO PIGMENTARIO DE LA RETINA OFTALMOLOGIA FACTORES DE EDAD CEGUERA ADULTOS
description	Abstract: Non-exudative age-related macular degeneration (NE-AMD), the main cause of blindness in people above 50 years old, lacks effective treatments at the moment. We have developed a new NE-AMD model through unilateral superior cervical ganglionectomy (SCGx), which elicits the disease main features in C57Bl/6J mice. The involvement of oxidative stress in the damage induced by NE-AMD to the retinal pigment epithelium (RPE) and outer retina has been strongly supported by evidence. We analysed the effect of enriched environment (EE) and visual stimulation (VS) in the RPE/outer retina damage within experimental NE-AMD. Exposure to EE starting 48 h post-SCGx, which had no effect on the choriocapillaris ubiquitous thickness increase, protected visual functions, prevented the thickness increase of the Bruch's membrane, and the loss of the melanin of the RPE, number of melanosomes, and retinoid isomerohydrolase (RPE65) immunoreactivity, as well as the ultrastructural damage of the RPE and photoreceptors, exclusively circumscribed to the central temporal (but not nasal) region, induced by experimental NE-AMD. EE also prevented the increase in outer retina/RPE oxidative stress markers and decrease in mitochondrial mass at 6 weeks post-SCGx. Moreover, EE increased RPE and retinal brain-derived neurotrophic factor (BDNF) levels, particularly in Müller cells. When EE exposure was delayed (dEE), starting at 4 weeks post-SCGx, it restored visual functions, reversed the RPE melanin content and RPE65-immunoreactivity decrease. Exposing animals to VS protected visual functions and prevented the decrease in RPE melanin content and RPE65 immunoreactivity. These findings suggest that EE housing and VS could become an NE-AMD promising therapeutic strategy.
format	Artículo
author	Dieguez, Hernán H. Calanni, Juan S. Romeo, Horacio Alaimo, Agustina González Fleitas, María F. Iaquinandi, Agustina Chianelli, Mónica S. Keller Sarmiento, María I. Sande, Pablo H. Rosenstein, Ruth E. Dorfman, Damián
author_facet	Dieguez, Hernán H. Calanni, Juan S. Romeo, Horacio Alaimo, Agustina González Fleitas, María F. Iaquinandi, Agustina Chianelli, Mónica S. Keller Sarmiento, María I. Sande, Pablo H. Rosenstein, Ruth E. Dorfman, Damián
author_sort	Dieguez, Hernán H.
title	Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
title_short	Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
title_full	Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
title_fullStr	Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
title_full_unstemmed	Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
title_sort	enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
publisher	Nature Research
publishDate	2022
url	https://repositorio.uca.edu.ar/handle/123456789/14600
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Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration

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