Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice

Abstract: During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible for the secretion of several factors involved in controlling bo...

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Autores principales: Quiroga, Sofia, Juárez, Yamila R., Marcone, María Paula, Vidal, María Agustina, Genaro, Ana María, Burgueño, Adriana Laura
Formato: Artículo
Lenguaje:Inglés
Publicado: Taylor & Francis 2022
Materias:
ESTRES PRENATAL
EXPRESION GENICA
HIGADO
TEJIDO ADIPOSO
RESISTENCIA A LA INSULINA
PROGRAMACION FETAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14594
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14594
record_format dspace
spelling I33-R139-123456789-145942024-03-26T10:59:09Z Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice Quiroga, Sofia Juárez, Yamila R. Marcone, María Paula Vidal, María Agustina Genaro, Ana María Burgueño, Adriana Laura ESTRES PRENATAL EXPRESION GENICA HIGADO TEJIDO ADIPOSO RESISTENCIA A LA INSULINA PROGRAMACION FETAL Abstract: During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible for the secretion of several factors involved in controlling body weight and energy expenditure, the regulation of insulin sensitivity, and the development of inflammation, among others. Moreover, the liver regulates glucose homeostasis and lipid metabolism, playing an essential role in developing insulin resistance. In this work, we analyzed if prenatal stress leads to alterations in metabolism and the relationship between these alterations and gene expression in the adipose tissue and the liver. Prenatal stress-exposed animals developed disturbances in the glucose and insulin response curve, showing in both tests higher glycemia than the control group. However, they did not exhibit increased body weight. At the same time, in the adipose tissue, we observed an increase in mRNA expression of Leptin and Resistin and a decrease in Adiponectin. In the liver, we observed a lower mRNA expression of several genes involved in glucose metabolism and fatty acid oxidation, such as Sirt1, Pgc1α, Pparα, among others. In both tissues, we observed a lower expression of inflammatory genes. These results suggest that prenatal stress exposure produces insulin resistance at both physiological and molecular levels without pro-inflammatory signaling or obesity. 2022-08-02T13:11:18Z 2022-08-02T13:11:18Z 2021 Artículo Quiroga, S. et al. Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice [en línea]. Stress: The International Journal on the Biology of Stress. 2021, 24 (6). doi: 10.1080/10253890.2021.1978425. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14594 https://repositorio.uca.edu.ar/handle/123456789/14594 10.1080/10253890.2021.1978425 34581257 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Taylor & Francis Stress: The International Journal on the Biology of Stress Vol.24, No.6, 2021
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES PRENATAL
EXPRESION GENICA
HIGADO
TEJIDO ADIPOSO
RESISTENCIA A LA INSULINA
PROGRAMACION FETAL
spellingShingle ESTRES PRENATAL
EXPRESION GENICA
HIGADO
TEJIDO ADIPOSO
RESISTENCIA A LA INSULINA
PROGRAMACION FETAL
Quiroga, Sofia
Juárez, Yamila R.
Marcone, María Paula
Vidal, María Agustina
Genaro, Ana María
Burgueño, Adriana Laura
Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
topic_facet ESTRES PRENATAL
EXPRESION GENICA
HIGADO
TEJIDO ADIPOSO
RESISTENCIA A LA INSULINA
PROGRAMACION FETAL
description Abstract: During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible for the secretion of several factors involved in controlling body weight and energy expenditure, the regulation of insulin sensitivity, and the development of inflammation, among others. Moreover, the liver regulates glucose homeostasis and lipid metabolism, playing an essential role in developing insulin resistance. In this work, we analyzed if prenatal stress leads to alterations in metabolism and the relationship between these alterations and gene expression in the adipose tissue and the liver. Prenatal stress-exposed animals developed disturbances in the glucose and insulin response curve, showing in both tests higher glycemia than the control group. However, they did not exhibit increased body weight. At the same time, in the adipose tissue, we observed an increase in mRNA expression of Leptin and Resistin and a decrease in Adiponectin. In the liver, we observed a lower mRNA expression of several genes involved in glucose metabolism and fatty acid oxidation, such as Sirt1, Pgc1α, Pparα, among others. In both tissues, we observed a lower expression of inflammatory genes. These results suggest that prenatal stress exposure produces insulin resistance at both physiological and molecular levels without pro-inflammatory signaling or obesity.
format Artículo
author Quiroga, Sofia
Juárez, Yamila R.
Marcone, María Paula
Vidal, María Agustina
Genaro, Ana María
Burgueño, Adriana Laura
author_facet Quiroga, Sofia
Juárez, Yamila R.
Marcone, María Paula
Vidal, María Agustina
Genaro, Ana María
Burgueño, Adriana Laura
author_sort Quiroga, Sofia
title Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
title_short Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
title_full Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
title_fullStr Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
title_full_unstemmed Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
title_sort prenatal stress promotes insulin resistance without inflammation or obesity in c57bl/6j male mice
publisher Taylor & Francis
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14594
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AT juarezyamilar prenatalstresspromotesinsulinresistancewithoutinflammationorobesityinc57bl6jmalemice
AT marconemariapaula prenatalstresspromotesinsulinresistancewithoutinflammationorobesityinc57bl6jmalemice
AT vidalmariaagustina prenatalstresspromotesinsulinresistancewithoutinflammationorobesityinc57bl6jmalemice
AT genaroanamaria prenatalstresspromotesinsulinresistancewithoutinflammationorobesityinc57bl6jmalemice
AT burguenoadrianalaura prenatalstresspromotesinsulinresistancewithoutinflammationorobesityinc57bl6jmalemice
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