c- Src and its role in cystic fibrosis

Abstract: Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is the...

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Autores principales: Massip Copiz, María Macarena, Santa Coloma, Tomás Antonio
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14562
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14562
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
spellingShingle FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
c- Src and its role in cystic fibrosis
topic_facet FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
description Abstract: Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the result from the loss of CFTR chloride transport function and its consequences, including a chronic and excessive c-Src signaling. On the other hand, c-Src, encoded by the SRC gene, is involved in diverse signaling mechanisms that regulate key cellular functions such as cell proliferation, apoptosis, oxidative stress, inflammation, and innate immunity. These c-Src-regulated cellular functions are also affected in CF; however, studies exploring a direct role of c-Src in the regulation of these cellular functions in CF are yet scarce and often controversial. Here we describe the c-Src regulation and functions, with emphasis in those altered in CF, and describe the role of CFTR as a “signaling molecule” that negatively modulates c-Src expression and activity. It is also discussed the emerging role of intracellular Cl− and IL-1 as intermediate signaling effectors between CFTR and c-Src.
format Artículo
author Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author_facet Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author_sort Massip Copiz, María Macarena
title c- Src and its role in cystic fibrosis
title_short c- Src and its role in cystic fibrosis
title_full c- Src and its role in cystic fibrosis
title_fullStr c- Src and its role in cystic fibrosis
title_full_unstemmed c- Src and its role in cystic fibrosis
title_sort c- src and its role in cystic fibrosis
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14562
work_keys_str_mv AT massipcopizmariamacarena csrcanditsroleincysticfibrosis
AT santacolomatomasantonio csrcanditsroleincysticfibrosis
bdutipo_str Repositorios
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