Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017

Abstract: Abstract Background Emerging pandemic viruses may have multiple deleterious effects on maternal health. This study examines the effects of a pandemic influenza virus on cause-specific maternal mortality time series, using Argentinian vital statistics. Methods We conducted a population-b...

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Autores principales: Critto, María Elena, Enríquez, Yordanis, Bravo, Miguel, De Janon Quevedo, Lenin, Weinbergf, Ruth, Etchegaray, Adolfo, Koch, Elard S.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
MORTALIDAD MATERNA
VIRUS DE LA INFLUENZA PORCINA
SALUD PUBLICA
VIRUS A-H1 N1
PANDEMIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14316
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14316
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MORTALIDAD MATERNA
VIRUS DE LA INFLUENZA PORCINA
SALUD PUBLICA
VIRUS A-H1 N1
PANDEMIA
spellingShingle MORTALIDAD MATERNA
VIRUS DE LA INFLUENZA PORCINA
SALUD PUBLICA
VIRUS A-H1 N1
PANDEMIA
Critto, María Elena
Enríquez, Yordanis
Bravo, Miguel
De Janon Quevedo, Lenin
Weinbergf, Ruth
Etchegaray, Adolfo
Koch, Elard S.
Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
topic_facet MORTALIDAD MATERNA
VIRUS DE LA INFLUENZA PORCINA
SALUD PUBLICA
VIRUS A-H1 N1
PANDEMIA
description Abstract: Abstract Background Emerging pandemic viruses may have multiple deleterious effects on maternal health. This study examines the effects of a pandemic influenza virus on cause-specific maternal mortality time series, using Argentinian vital statistics. Methods We conducted a population-based natural experiment from national vital records of maternal deaths between 1980 and 2017. Joinpoint regression models were used to model time series of the maternal mortality ratio (MMR). The sensitivity of the registry to detect the effects of the pandemic H1N1 2009 influenza virus on cause-specific MMR was analysed using a panel of parallel interrupted time series (ITS). Findings Over this 38-year study, the MMR decreased by 58¢6% (69¢5 to 28¢8 deaths/100,000 live births), transitioning from direct obstetric causes (67¢0 to 21¢1/100,000 live births; 68¢4% decrease) to indirect causes (2¢6 to 7¢7/ 100,000 live births; 196¢2% increase). The regression analysis showed an average reduction of -2¢2%/year (95% CI: -2¢9 to -1¢4) with 2 join points in the total trend (1998 and 2009). Parallel ITS analyses revealed the pandemic H1N1 virus had an increasing effect on mortality from the respiratory system- and sepsis-related complications (level change 4¢7 and 1¢6/100,000 live births respectively), reversing after the outbreak. No effect was found on MMR from hypertensive disorders, haemorrhage, abortive outcomes, other direct obstetric causes, and indirect non-respiratory comorbidities. Interpretation The Argentinian maternal death registry appears sensitive to detect different effects of emerging infectious epidemics on maternal health. In a population-based natural experiment, pandemic H1N1 virus impacted maternal mortality almost exclusively from the respiratory system- and sepsis-related complications.
format Artículo
author Critto, María Elena
Enríquez, Yordanis
Bravo, Miguel
De Janon Quevedo, Lenin
Weinbergf, Ruth
Etchegaray, Adolfo
Koch, Elard S.
author_facet Critto, María Elena
Enríquez, Yordanis
Bravo, Miguel
De Janon Quevedo, Lenin
Weinbergf, Ruth
Etchegaray, Adolfo
Koch, Elard S.
author_sort Critto, María Elena
title Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
title_short Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
title_full Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
title_fullStr Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
title_full_unstemmed Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017
title_sort impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, argentina 1980-2017
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14316
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